EPHX2

(redirected from Cytosolic epoxide hydrolase)

EPHX2

A gene on chromosome 8p21 that encodes epoxide hydrolase-2. Epoxide hydrolases are critical biotransformation enzymes that activate and detoxify epoxides by breaking down aromatic compounds to dihydrodiols, which can be conjugated and excreted from the body.
 
Molecular pathology
EPHX2 mutations are associated with familial hypercholesterolaemia.
References in periodicals archive ?
Affinity purification of cytosolic epoxide hydrolase using derivatized epoxy-activated Sepharose gels.
Although LTX-diol identified as the peak II component isolated from ground corncob in this study is an auto-oxidation product of linoleic acid in animals, a cytosolic epoxide hydrolase can metabolize the epoxy fatty esters to their vicinol diols (Halankar et al.
The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with cytosolic epoxide hydrolase.
Microsomal and cytosolic epoxide hydrolase and glutathione S-transferase activities in the gill, liver, and kidney of the rainbow trout, Salmo gairdneri: Baseline levels and optimization of assay conditions.
Spectrophotometric substrates for cytosolic epoxide hydrolase.