Conclusion: The most common hematological disorders in SLE patients are lymphopenia and anemia, and patients must be further examined for APS and renal involvement if they suffer cytopenia
Peripheral blood cytopenia
, with at least two of the following: hemoglobin less than 9 g/dL (for infants less than 4 weeks hemoglobin less than 10 g/dL), platelets less than 100,000/microL absolute neutrophil count less than 1000/microL.
However, bilirubin levels steadily increased, and cytopenia
persisted with a total leukocyte count < 1 x [10.
18%) with features of dyserythropoiesis and ineffective erythropoiesis as the cause of the cytopenias
All patients exhibited cytopenias
during their stay, although cell counts often fluctuated markedly, most commonly following transfusion of blood products.
(affecting [greater than or equal to] 2 of 3 lineages in the peripheral blood): i.
5 2) Splenomegaly 3) Cytopenias
(affecting at least 2 of 3 lineages in the peripheral blood) 4) Hypertriglyceridemia (>265 mg/dL, fasting) and/or hypofibrinogenemia (<150 mg/dL) 5) Hemophagocytosis in bone marrow, spleen, lymph nodes, or liver 6) Low or absent NK-cell activity 7) Ferritin >500 ng/mL 8) Elevated soluble CD25 (alpha chain of soluble IL-2 receptor)
10) As with other HIV-associated cytopenias
, the etiology of thrombocytopenia is multifactorial.
Of the nine cases of myelodysplastic syndrome, four were refractory anemia (RA), one was refractory anemia with ring sideroblast (RARS), two were refractory cytopenia
with multilineage dysplasia and two had refractory Anemia with excess blast (RAEB).
Preclinical studies presented compelling evidence that Syk inhibition may have therapeutic value in the treatment of rheumatoid arthritis and other forms of arthritis, systemic lupus erythematosus, autoimmune cytopenias
, and allergic and autoinflammatory diseases.
It should be considered in patients with prolonged fever, splenomegaly and cytopenias
5 2 factor Bone marrow <5 5--10 NA 11-- 21--30 blasts (%) 20 Karyotype Good Intermediate Poor NA NA Cytopenias
0/1 2/3 NA NA NA Median survival by age group (years) IPSS [greater >60 [greater than >70 classification than or (n=611) or equal (n=371) equal to]70(n=445) to]60 (n=205) Low (n=267) 11.