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cytomegalovirus retinitis |
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retinitis, cytomegalovirus (CMV retinitis) A rare, chronic, diffuse infection of the retina caused by the cytomegalovirus (CMV), a member of the herpesvirus group. It affects people with an impaired immune system as a result of either AIDS, organ transplantation or chemotherapy for some malignancies such as leukaemia. The signs are whitish retinal lesions, which look granular (not fluffy, cotton-wool spots). These lesions progress into retinal necrosis with absolute visual field loss in that area. The lesions are usually accompanied by haemorrhages. Eventually the lesions coalesce and involve the entire fundus, resulting in complete visual loss. In the initial phase of the disease most patients are usually asymptomatic while those with symptoms will complain of floaters, blurred vision, photopsia, scotomas, metamorphopsia, etc. In some cases, retinal detachment follows the disease. Treatment with dihydroxy propoxymethyl guanine and ganciclovir produces some regression of the disease. See acquired immuno-deficiency syndrome.
cytomegalovirus retinitis Ophthalmology CMV infection of the eye, a common opportunistic infection in AIDS, a complication of disseminated CMV infection Clinical Retinal inflammation, blindness Management Antivirals–eg, foscarnet,
cidofovir, gancyclovir, systemically and as a ganciclovir implant Prognosis Without treatment, retinal necrosis, vision loss How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The antiviral medication cidofovir was recently approved for the treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Approved March 5, 1996 for the treatment of cytomegalovirus retinitis in patients with AIDS. Swann suffers from cytomegalovirus retinitis, a disease common among AIDS patients that can lead to blindness within a week. |
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