cytokeratin


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Related to cytokeratin: cytokeratin 18, cytokeratin 20, cytokeratin 7

ker·a·tin

(ker'ă-tin),
Collective name for a group of proteins that form the intermediate filaments in epithelial cells. Keratins have a molecular weight between 40 kD and 68 kD and are separated one from another by electrophoresis and isoelectric focusing; thus separated, they are sequentially numbered from 1-20, and also subdivided into low, intermediate, and high molecular weight proteins. According to their isoelectric mobility they are either acidic or basic. In general, each acidic keratin protein has its basic equivalent with which it is paired to form the intermediate filaments; some keratin proteins, however, occur unpaired. Various epithelial cells contain different keratin proteins, in a tissue-specific manner. Antibodies to keratin proteins are widely used for histologic typing of tumors, and are especially useful for distinguishing carcinomas from sarcomas, lymphomas, and melanomas.
Synonym(s): ceratin, cytokeratin
[G. keras (kerat-), horn, + -in]

cytokeratin

A global term for the family of intermediate filament proteins of epithelial origin; the pattern of cytokeratins (CKs) expressed may help differentiate colorectal from lung carcinomas based on low and high molecular weight types.

ker·a·tin

(ker'ă-tin)
A scleroprotein or albuminoid present in hair and nails; it contains a relatively large amount of sulfur, is insoluble in gastric juice, and is sometimes used for coating tablets that are intended to be dissolved only in the intestine.
Synonym(s): cytokeratin.
[G. keras (kerat-), horn, + -in]

cytokeratin

(sīt″ŏ-ker′ăt-ĭn) [ cyto- + keratin],

CK.

Any of the intermediate-sized filament proteins found in epithelial cells. Antibodies against CKs are used to detect specific cell types. The detection of unique CKs helps in the immunohistochemical identification of the origin of specific cancers.
References in periodicals archive ?
Based on the present study, it is concluded that Cytokeratin 19 can be used as a good diagnostic marker for papillary thyroid carcinoma.
66-69) When a predominantly spindle cell lesion with limited tissue availability is encountered in the bladder, an immunohistochemical panel composed of ALK-1, SMA, desmin, cytokeratin (AE1/AE3), p63, and HMWCK or CK5/6 is potentially helpful (Table 5).
Basal Cytokeratin and Epidermal Growth Factor Receptor Expression are not Predictive of BRCAl Mutation Status in Women with Triple-Negative Breast Cancers.
La tecnica de inmunohistoquimica por el metodo de peroxidasa endogeno fue utilizada para Pancitoqueratina (Mouse anti Cytokeratin (Pan) AE1/AE3, Invitrogen, Frederick, USA) (Dilucion 1:200 [micro]l) y Vimentina (Mouse anti Vimenetin (V9), Invitrogen, Frederick, USA) (Dilucion 1:1000 [micro]l), ambas de marcacion citoplasmatica.
The distinction from granular cell variants of renal cell carcinoma may be made by the presence in the later of large cells with abundant granular cytoplasm, ill-defined cell borders, prominent nucleoli, and intermixed variable number of clear cells, negative Hale's colloidal iron stain, cytokeratin, EMA, and positive reactions for vimentin, S100 and CD68.
Cytokeratin 6A-derived peptides emerged the winners, and surprisingly, peptide fragments as short as 10 amino acids were effective.
Cytokeratin can aid in the distinction between a PPP and a carcinoid, but is not absolutely diagnostic (1,11).
Immunohistochemical staining for alpha-fetoprotein (AFP) and cytokeratin were performed in selected slides.
This study also localized Bax expression relative to the expression of CYP1A1 and cytokeratin 8/18, an alveolar type II cell marker.
The mediastinal tumor samples taken from our patient stained positively for vimentin, muscle-specific actin, and desmin and were negative for cytokeratin AE 1/3, cytokeratin 7, cytokeratin 20, epithelial membrane antigen (EMA), calretinin, S100 protein, melanoma antibody (HMB45), and leukocyte common antigen.