CYP3A4

(redirected from Cytochrome P450 3A4)

CYP3A4

A gene on chromosome 7q21.1 that encodes a member of the cytochrome P450 superfamily of monooxygenases, which catalyse reactions in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 localises to the endoplasmic reticulum; its expression is induced by glucocorticoids and drugs. It metabolises roughly half of the drugs in current use today—e.g., paracetamol (acetaminophen), codeine, cyclosporin A, diazepam and erythromycin—as well as steroids and carcinogens.

CYP3A4

One isoenzyme form of the cytochrome P450 system involved in the metabolism of many drugs. Drugs that alter this enzyme system can influence the metabolism of other agents taken by patients and cause unanticipated toxic effects.
References in periodicals archive ?
Moreover, individuals absorb drugs with varying efficiency, depending on the amount of cytochrome P450 3A4 they have.
Study 008 is a pharmacokinetic (PK) study being done at Duke University and it is designed to examine the effect of a potent inhibitor of Cytochrome P450 3A4 on FV-100 pharmacokinetics, allowing the Company to better understand potential drug-drug interactions and to further optimize treatment with FV-100.
Changes to the clinical pharmacology section of the label note that trazodone--indicated for the treatment of depression--is a substrate of the cytochrome P450 3A4 (CYP3A4) enzyme and that trazodone metabolism can be inhibited by the CYP3A4 inhibitors ketoconazole, ritonavir, and indinavir.
Cytochrome P450 3A4 (CYP3A4) contributes to the metabolism of a wide variety of drugs and endogenous substrates, such as steroid hormones (1, 2).
The clinical briefing, titled "Human Clinical Trials With AVI-4557 Targeting Cytochrome P450 3A4," will be presented by Patrick L.
WARNING: ADDICTION, ABUSE, AND MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; NEONATAL OPIOID WITHDRAWAL SYNDROME; AND CYTOCHROME P450 3A4 INTERACTION
The two patents awarded to Astex are European patent EP1 438 337(1) covering the use of the crystal structure of human cytochrome P450 2C9 and GB 2 408 609(2) which covers the use of the crystal structure of human cytochrome P450 3A4.
AVI-4557 targets human cytochrome P450 3a4 (P450) and has been used clinically in four drug metabolism trials.
John's wort boosts hepatic cytochrome P450 3A4 metabolic activity.
Abstract #367 Cytochrome P450 3A4 and 1A2 induction in the immortalized hepatocyte line, Fa2N-4, and comparison with primary cultures of human hepatocytes.
The PK study, to be conducted at Duke University in early 2015, is designed to further understand the effect of a potent inhibitor of Cytochrome P450 3A4 on the pharmacokinetics of FV-100, allowing ContraVir to better understand the potential for clinically important drug-drug interactions and to further optimize treatment for Phase 3 development.

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