Cytochrome P-450 enzymes

Cytochrome P-450 enzymes (sīˑ·t·krōmˈ pēˑ-fōrˈ fifˈ·tē enˑ·zīmz), oxygenating catalysts responsible for the reactions used by the body, especially the liver, to detoxify drugs and other substances.
References in periodicals archive ?
In theory at least, SSRIs that inhibit cytochrome P-450 enzymes, such as fluoxetine and fluvoxamine (Luvox), may alter concentrations of some oral antidiabetic drugs.
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes.
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians.
The volatile organic compounds are either degraded by cytochrome P-450 enzymes or excreted in the breath.
The hepatic metabolism of many medications is mediated by certain cytochrome P-450 enzymes, and the antidepressants fluvoxamine and nefazodone interfere with certain P-450 enzymes.
At the end of the 4 weeks, the researchers killed the fish and extracted their cytochrome P-450 enzymes, which break down chemicals.
Both alcohol and tobacco are known to induce hepatic cytochrome P-450 enzymes, which can lead to altered metabolism of many drugs," he said.
Cytochrome P-450 enzymes have been implicated in most drug-drug interactions, including many cases of hepatotoxicity.
Drugs that induce cytochrome P-450 enzymes, such as carbamazepine, oxcarbazepine, and topiramate, have been linked with a raised contraceptive failure rate--at least 6% per year, and in some cases as high as 20%, compared with 1% per year in non-treated populations.
In addition, they have little effect on cytochrome P-450 enzymes and are associated with "a paucity of drug interactions," he said.

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