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cytochrome P-450 |
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cytochrome P-450 Etymology: Gk, kytos, cell, chroma, color a protein involved with extramitochondrial electron transport in the liver and during drug detoxification. cytochrome P-450 Clinical pharmacology A superfamily of heme-containing enzymes–CYPs of the electron transport chain, which have multiple activities, including activation of molecular O2 for incorporation into unactivated
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| It is the case of statins that undergoes different metabolism via cytochrome P-450 (CYP) superfamily: lovastatin, simvastatin and atorvastatin are mostly metabolized by CYP3A isoenzymes, fluvastatin by CYP2C9, while pravastatin and rosuvastatin are not significantly metabolized by this system. Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. The hepatic metabolism of many medications is mediated by certain cytochrome P-450 enzymes, and the antidepressants fluvoxamine and nefazodone interfere with certain P-450 enzymes. |
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