cysteamine


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cysteamine

 [sis-te´ah-mēn″]
a sulfhydryl amine that is part of coenzyme A; it reduces intracellular cystine levels and is used in treatment of nephropathic cystinosis; administered orally.

cys·te·a·mine

(sis-tā'a-mēn),
2-Aminoethanethiol; a sulfhydryl compound used experimentally to produce ulcers in rats and as a radioprotective agent; antidote to acetaminophen.

cysteamine

[siste′ämēn′]
a sulfhydryl amine that is part of coenzyme A. It reduces intracellular cystine levels and is used in treatment of nephropathic cystinosis. It is administered orally.

cysteamine

A stable aminothiol and metabolite of the amino acid cysteine.

Physiologic role
Cysteamine forms coenzyme A by combining with pantothenate and adenosine triphosphate.

Potential therapeutic role
Cysteamine has been in clinical trials for managing Batten disease, cystinosis, non-alcoholic steatohepatitis and Huntington's disease.

cysteamine

Mercaptamine, a drug used to treat NEPHROPATHIC CYSTINOSIS and prescribable only by urological specialists. A brand name is Cystagon.
References in periodicals archive ?
The wide range in patients reflects a diverse patient population that includes those highly compliant with medication, those with low compliance or taking low cysteamine dosages, in addition to differences in genotype.
Early diagnosis and treatment with renal transplantation and oral cysteamine can change the course of this disease.
Supplementation with cysteamine during maturation and embryo culture on embryo development of prepubertal goat oocytes selected by the brilliant cresyl blue test.
Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro.
Cysteamine or bmercaptoethanol added to a defined maturation medium improves blastocyst formation of porcine oocytes after intracytoplasmic sperm injection.
RP103 is an enteric coated, microbead formulation of cysteamine bitartrate that has been formulated to be sprinkled onto food for administration to patients too young to take oral capsules.
de Matos and Furnus [6] reported that addition of tiol compounds such as cysteamine during bovine IVM caused the high intracellular GSH level and improved bovine embryo development and quality.
Cystinosis is currently treated with cysteamine, but this produces unpleasant side effects and has to be administered four times a day as up to 70% is wasted through the body's metabolism.
The tiny drug developer announced positive Phase 2a clinical trial results from its pilot study of delayed-release cysteamine bitartrate in 11 adolescent patients with non-alcoholic steatohepatitis ("NASH"), a progressive form of liver disease believed to affect 5% to 11% of the U.
Table IV Causes of blood-borne halitosis Odorant Systemic diseases * Hepatic failure/liver cirrhosis * Dimethyl sulfide * Uremia/kidney failure * Dimethylamine, trimethy lamine * Diabetic ketoacidosis/diabetes mellitus * Acetone Metabolic disorders * Isolated persistent * Dimethyl sulfide hypermethioninemia * Trimethylamine * Fish odor syndrome, trimethy laminuria Medication * Disulfiram * Carbon disulfide * Dimethyl sulphoxide * Dimethyl sulfide * Cysteamine * Dimethyl sulfide Food * Garlic * Ally1 methyl sulfide * Onion * Methyl propyl sulfide Tangerman A.
Use of cysteamine in the buffalo oocyte and embryo culture media were reported to increase the intracellular glutathione synthesis, which in turn protects the cells from oxidative stress, thus increasing the blastocyst yield (Gasparrini et al.
Summary: TEHRAN (FNA)- Iranian chemists made a modified glassy carbon electrode by functionalized carbon nanotube which is able to electrochemically measure the cysteamine present in biological specimens.