anaphase promoting complex

(redirected from Cyclosome)

anaphase promoting complex

A large protein complex of 11 to 13 proteins—including cullin (Apc2), RING (Apc11), and other proteins of as yet unknown functions—which is an E3 ubiquitin ligase that targets cell cycle proteins for degradation by the 26S proteasome.
References in periodicals archive ?
A substance called APC (Anaphase Promoting Complex), or cyclosome, then liberates a "sister separating" protein, Esp1, which would otherwise be inhibited by Pds1p.
In oridonin-treated HepG2 cells, the up-regulation of Stil might inhibit the formation of 20S cyclosome complex (Yamashita et al.
He earned a PhD from the Technion-Israel Institute of Technology, completing his thesis on the "Role of cyclosome in the regulation of cyclin degradation.