cyclooxygenase

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Related to Cyclooxygenase inhibitors: Reye's syndrome, NSAIDs, Cyclooxygenase 2 inhibitors

cyclooxygenase

 [si″klo-ok´sĭ-jĕ-nās]
an activity of the enzyme prostaglandin endoperoxide synthase.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase

cyclooxygenase

/cy·clo·oxy·gen·ase/ (-ok´sĭ-jen-ās) a component of prostaglandin synthase (q.v.).

cyclooxygenase

(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
n.
1. See COX-1.
2. See COX-2.

cyclooxygenase

[si′klō·ok′səjĕnās]
an activity of the enzyme prostaglandin endoperoxide synthase.

Cyclooxygenase

An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
References in periodicals archive ?
1) Treatment of OA cartilage with commonly utilized cyclooxygenase inhibitors increases LTB4 production, which is associated with a marked change in the transcription of multiple cytokine and growth factor dependent genes which are prerequisite for normal cartilage homeostasis.
To determine the mechanism of action of Ch1LW-induced relaxation, we examined the effects of nitric oxide synthase and cyclooxygenase inhibitors and muscarinic receptor antagonist in endothelium-intact aortic rings.
The classification of cyclooxygenase inhibitors (editorial).
1998) showed that 2',5'-dihydroxychalcone may be a promising antiinflammatory agent, because it is a potent mediator and cyclooxygenase inhibitor.
As the potential for therapeutic applications of the cyclooxygenase inhibitors continues to increase, vigilance for adverse reactions and interactions of this class of drugs must also increase.

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