cycloheximide

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cycloheximide

(sī″klō-hĕks′ă-mīd)
A cytotoxic protein that inhibits the synthesis of proteins by cells.

cycloheximide

an antibiotic produced by Streptomyces griseus that inhibits protein synthesis. It is too toxic and nonselective for common clinical use, but is used in treatment of cancers and management of graft-versus-host reactions following transplantation. Also used agriculturally for the control of fungal diseases of plants and turf and as a bacterial inhibitor in selective media for culturing fungi.
References in periodicals archive ?
3], 10 [micro]g/mL gentamicin (MP Biomedicals, Solon, OH, USA); 25 [micro]g/mL vancomycin (Acros Organics, Morris Plains, NJ, USA); 25 units/mL nystatin (MP Biomedicals), 375 [micro]g/mL amphotericin B (PharmaTek, Huntington, NY, USA); 1 [micro]g/mL cyclohexamide for 48 h and harvested as described (18,19).
After centrifugation, the inocula were removed and replaced with CMGH plus 1 [micro]g/mL cyclohexamide and maintained at 37[degrees]C in 5% C[O.
Two milliliters of CMGH without cyclohexamide were added to the solidified IAO.
trachomatis serovar LGV-L1 and LGV-L2 were propagated in a semiconfluent McCoy cell sheet for 48-72 h in EMEM media with 10% v/v FCS and cyclohexamide [2ug [mL.
marketed (FDA approved) antivirals, including ribavirin (for RSV, respiratory syncytal virus) and related compounds (5 cpds); formycin analogs and polyoxometalates and dendrimers and 5 non carbocyclic adenosine analogues (totaling 11 new cpds); new apoptosis inhibitors and new cyclin-dependent kinase inhibitors (6 cpds) as well as adenosine kinase inhibitors (3 cpds); plus miscellaneous phospolipase, attachment / penetration and bunga virus inhibitors, plus cyclohexamide and a coumadin analog (totaling 7 cpds).
We have not performed experiments in the presence of cyclohexamide.