cyclooxygenase

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Related to Cyclo-oxygenase: Cyclooxygenase 2 inhibitors

cyclooxygenase

 [si″klo-ok´sĭ-jĕ-nās]
an activity of the enzyme prostaglandin endoperoxide synthase.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase

cyclooxygenase

/cy·clo·oxy·gen·ase/ (-ok´sĭ-jen-ās) a component of prostaglandin synthase (q.v.).

cyclooxygenase

(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
n.
1. See COX-1.
2. See COX-2.

cyclooxygenase

[si′klō·ok′səjĕnās]
an activity of the enzyme prostaglandin endoperoxide synthase.

Cyclooxygenase

An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
References in periodicals archive ?
Nonsteroidal antipyretic drugs inhibit prostaglandin synthesis by decreasing cyclo-oxygenase (Dascombe, 1985).
Since indomethacin is an inhibitor of the enzyme cyclo-oxygenase, the authors suggest that this inhibition confirms the presence of the enzyme in the plant extracts.
amazonica, anti-inflammatory activity relied on cyclo-oxygenase inhibition.
The enzyme, called cyclo-oxygenase (COX), causes the local production of chemicals called prostaglandins, which amplify pain signals.
Aspirin and most other nonsteroidal anti-inflammatory drugs work by blocking prostaglandin synthesis by cyclo-oxygenase, another enzyme that can initiate arachidonic acid breakdown.
Nonsteroidal anti-inflammatory drugs work by blocking an enzyme called cyclo-oxygenase, which exists in the body in two forms, COX-1 and COX-2.
Inhibits cyclo-oxygenase in the central nervous system, which inhibits prostaglandin synthesis.
The paper, titled "Verification of a Decision Analytic Model Assumption Using Real-World Practice Data: Implications for the Cost Effectiveness of Cyclo-oxygenase 2 Inhibitors (COX-2s)," was published in the December 2003 issue of the American Journal of Managed Care.
Previous experimental studies had shown that Lyprinol(R) was effective in inhibiting -5-lipoxygenase and cyclo-oxygenase pathways responsible for production of eicosanoids, including leukotrienes and prostaglandins, the aim of that study was to assess its effect on symptoms, peak expiratory flow (PEF) and hydrogen peroxide (H2O2) in expired breath condensate as a marker of airway inflammation in patients with steroid-naive atopic asthmatics.
Conventional NSAIDs such as naproxen, as well as selective cyclo-oxygenase (COX)-2 inhibitors, are known to affect blood pressure adversely and can counteract the benefits of antihypertensive agents.