Nonsteroidal antipyretic drugs inhibit prostaglandin synthesis by decreasing cyclo-oxygenase
Since indomethacin is an inhibitor of the enzyme cyclo-oxygenase
, the authors suggest that this inhibition confirms the presence of the enzyme in the plant extracts.
2: a pharmacological target for the prevention of cancer.
amazonica, anti-inflammatory activity relied on cyclo-oxygenase
The enzyme, called cyclo-oxygenase
(COX), causes the local production of chemicals called prostaglandins, which amplify pain signals.
Aspirin and most other nonsteroidal anti-inflammatory drugs work by blocking prostaglandin synthesis by cyclo-oxygenase
, another enzyme that can initiate arachidonic acid breakdown.
Nonsteroidal anti-inflammatory drugs work by blocking an enzyme called cyclo-oxygenase
, which exists in the body in two forms, COX-1 and COX-2.
in the central nervous system, which inhibits prostaglandin synthesis.
The paper, titled "Verification of a Decision Analytic Model Assumption Using Real-World Practice Data: Implications for the Cost Effectiveness of Cyclo-oxygenase
2 Inhibitors (COX-2s)," was published in the December 2003 issue of the American Journal of Managed Care.
Previous experimental studies had shown that Lyprinol(R) was effective in inhibiting -5-lipoxygenase and cyclo-oxygenase
pathways responsible for production of eicosanoids, including leukotrienes and prostaglandins, the aim of that study was to assess its effect on symptoms, peak expiratory flow (PEF) and hydrogen peroxide (H2O2) in expired breath condensate as a marker of airway inflammation in patients with steroid-naive atopic asthmatics.
They work by blocking an enzyme called cyclo-oxygenase
, which exists in the body in two forms, COX-1, which helps protect the stomach and intestine, and COX-2, which is associated with pain and inflammation.
Conventional NSAIDs such as naproxen, as well as selective cyclo-oxygenase
(COX)-2 inhibitors, are known to affect blood pressure adversely and can counteract the benefits of antihypertensive agents.