cyclins


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cyclins

(sī′klĭnz)
A group of intracellular proteins that regulate the cell cycle, i.e., cell growth and division. Some cyclins, including cyclins D and E, are overexpressed in human breast cancer cells.

cyclins

Regulatory subunits of the kinases involved in the eukaryotic cell cycle. Cyclins are proteins whose concentration in the cells increases and decreases in phase with the cell cycle. Passage through the cycle is controlled by cyclin-dependent kynase complexes which are inactive unless associated with a cyclin.

cyclins

a set of related proteins that regulate the passage of cells through the cell cycle by forming complexes with cyclin-dependent protein kinases.

cyclins-dependent protein kinase (Cdk)
forms complexes with cyclins to become active in activating stages of the eukaryotic cell cycle.
References in periodicals archive ?
We didn't expect cyclin D3 to ramp up beta cell replication so strongly when it was used with either cdk4 or cdk6.
The cyclins and cyclin-dependent kinase inhibitors in normal regulation of proliferation and differentiation.
The rise and fall of cyclin concentrations move a cell through the four stages of its life cycle: growth, DNA replication, preparation for cell division, and cell division itself (SN: 4/23/94, p.
Nikaido et al (11) reported that about 40% of endometrial carcinomas overexpress cyclin D1 and proposed that cyclin D1 dysregulation may have a role in endometrial carcinogenesis.
The journal article is entitled "G(1) arrest of U937 cells by ONCONASE is associated with suppression of cyclin D3 expression, induction of p16(INK4A), p21(WAF1/CIP1) and p27(KIP) and decreased pRb phosphorylation".
Rabbit monoclonal antibody against activated caspase-3, PARP (cleaved p85), cyclin B1, cyclin-dependent kinase 1 (Cdk1), phospho-Cdkl (Tyr15), cell division cycle (Cdc) 25c, and GAPDH were obtained from Santa Cruz (Santa Cruz, CA, USA).
Cyclin D1 gene amplification was observed diffusely in both components, whereas no CD1 gene amplification was observed in the adjacent nonneoplastic tissue.
The main components of RB pathway involves five family proteins; retinoblastoma tumor suppressor RB- family of pocket proteins (p110, p107, p130), E2F-family of transcription factors (heterodimers of E2F1-8 with DP1-2), cyclins (D and E-type), cyclin-dependent protein kinases (cdk4, cdk6) and cyclin-dependent kinase inhibitor CDKIs (p16Ink4a, p15Ink4b, p18Ink4c and p19Ink4d).
To investigate whether CA blocked the progression through the cell cycle by inhibiting the levels of the Cyclins and consequently the activities of CDKs, we first performed immunoblot analysis of CA treated and control PT2 cells with specific antibodies directed against Cyclin A and B1.