The journal article is entitled "G(1) arrest of U937 cells by ONCONASE is associated with suppression of cyclin
D3 expression, induction of p16(INK4A), p21(WAF1/CIP1) and p27(KIP) and decreased pRb phosphorylation".
The kinase activity of Cdk1 is controlled during the cell-cycle both by its association with cyclin
B1 and by phohphorylation and dephosphorylation on residues Thr14 and Tyr15 crucial for the [G.
This is encouraging as Cyclacel makes progress in building a competitive pipeline in the cell cycle area with additional drug candidates from our CYC400 CDK inhibitor, CYC103 Cyclin
Groove Inhibitor and CYC102 PCNA Inhibitor programmes.
By immunohistochemistry, cyclin
D1 protein is overexpressed in the majority of MCL cases.
Differential prognostic impact of the cyclins
E and B in premenopausal and postmenopausal women with lymph node-negative breast cancer.
In this research it was clearly shown that hyperplastic intima was mainly composed of VSMC, and cyclin
3 mg/ml of dried plant material) which correlated with cyclin
D1- and Cdc25A suppression and p21 induction.
This study demonstrates differences in cyclin
D1 overexpression in both endometrial surface metaplasia and endometrial glandular hyperplasia and carcinoma.
NF-kappaB function in growth control: regulation of cyclin
D1 expression and G0/Gl-to-S-phase transition.
Their activities are tightly controlled by associated cyclins
and other cell cycle regulators, including tumor suppressor genes such as p21 and the retinoblastoma gene product.
Osaka, Japan) has patented a novel protein having a high degree of homology to the amino acid sequence of the so-called cyclin
box which is characteristic of cyclins
: they are herein referred to as "human cyclin
I" or "human cyclin
The discovery of CDKs and cyclins
and their role in checkpoint control of the cancer cell cycle has been honored with the 2001 Nobel Prize for Medicine and Physiology.