cyclin-dependent kinase

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cyclin-dependent kinase (CDK)

a protein kinase that is activated by cyclin.

cyclin-dependent kinase

Abbreviation: CDK
A family of enzymes involved in regulation of the cell cycle. They serve as targets for pharmacological manipulation of this cycle, particularly during the unregulated proliferation of tumor cells.
See also: kinase
References in periodicals archive ?
Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation to abemaciclib, a cyclin-dependent kinase (CDK) 4 and 6 inhibitor, for patients with refractory hormone-receptor-positive (HR+) advanced or metastatic breast cancer.
Cyclin-dependent kinases are enzymatic proteins that are integrally involved in cellular metabolism, renewal and signaling, and are thought to play key roles in the growth of cancers.
p27(KIP1) is a member of the CIP1/KIP1 family of cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene.
Cyclin D1 regulates G1 phase progression via cyclin-dependent kinase 4/6-dependent phosphorylation and partial inactivation of the repressive activity of the retinoblastoma protein.
Phase II Study of the Cyclin-Dependent Kinase (CDK) Inhibitor Dinaciclib (SCH 727965) In Patients with Advanced Acute Leukemias" (Abstract # 3287, Poster board #: III-66)
This is due to the fact that tumor cells frequently lose the endogenous inhibitors of cyclin-dependent kinases.
The anti-tumor agent, currently in Phase I/II testing, targets cyclin-dependent kinases (CDK) that are involved in crucial cellular functions such as tumor cell proliferation and survival signaling.
The transition through G1 to S phase is regulated by cyclins, cyclin-dependent kinases (CDK)-CDK4 and CDK6 and their inhibitors.
Sample topics include centrosomes in checkpoint responses, DNA damage response and the balance between cell survival and cell death, and targeting cyclin-dependent kinases with small molecule inhibitors.

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