About Encycle Therapeutics Encycle Therapeutics is a start-up drug discovery company that is exploiting a novel synthetic method to generate "nacellins," more drug-like cyclic peptides
Academic partners have unique knowledge and technologies on supercharged viral proteins-derived cell-penetrating peptides (eg from Dengue virus) and ultra-resistant cyclic peptides
that may be transferred to the industrial partners, which in turn have specialized proprietary technologies on anticancer and/or peptide drugs technologies.
Beginning with a comprehensive chapter outlining computational methods in peptide and protein design, it goes on to explore peptidomimetics, design of cyclic peptides
, the role of carbohydrates in the process of design, and de novo methods.
Bicycle Therapeutics applies powerful biological selection techniques in combination with the Pepscan technology to identify and optimize chemically constrained cyclic peptides
with high target specificity and binding affinities.
HPLC of extracts of selected samples from Lake Ladoga revealed a rather high diversity of toxins, including hepatotoxic cyclic peptides
(microcystins), enzyme inhibitors (cytoxins), and numerous unidentified substances (Table 2; Fig.
Sensitivity was enhanced substantially without loss of specificity by the use of synthetic cyclic peptides
derived from the sequence of human filaggrin with a high content of citrullin [cyclic citrullinated peptides (CCP)] as antigen (13).
The book contains chapters on synthetic advancements in the chemical classes of carbohydrates, macrolides, polyethers, alkaloids, aromatic heterocycles, carboaromatics, terpenes, steroids, enediynes, linear peptides and amino acids, cyclic peptides
At the structural heart of the drugs are rings, called cyclic peptides
, that are composed of either six or eight amino acids.
The hepatotoxins produced by cyanobacteria include cyclic peptides
called microcystins and nodularins.
The parameters optimized for simple amides were completely unsatisfactory for this and other cyclic peptides
we have studied; shifting the position of the chromophore tended to produce unsatisfactory wavelength shifts.
5,942,492, "Cyclic Peptides
That Bind To Urokinase-Type Plasminogen Activator Receptor" covers a broad class of cyclic peptides
that Angstrom is developing to inactivate or alternatively to target a key receptor involved in the tumor angiogenesis and tumor metastasis.
CAMBRIDGE, England -- Bicycle Therapeutics Ltd, a new biotechnology company developing a novel technology platform for the identification and optimisation of chemically constrained cyclic peptides
with high target specificity and binding affinity, has signed a License agreement with the Ecole Polytechnique Federale de Lausanne (EPFL) in Lausanne, Switzerland and has secured additional seed funding from SR One, the independent corporate venture fund of GlaxoSmithKline, and SV Life Sciences.