Merkel cell carcinoma

(redirected from Cutaneous neuroendocrine carcinoma)

Merkel cell carcinoma

[mer′kəl, mur′kəl]
Etymology: Friedrich S. Merkel, German anatomist and physiologist, 1845-1919
a rapidly growing malignant skin tumor that tends to occur on sun-exposed surfaces of older Caucasian individuals. It is composed of small cells in a trabecular pattern that contain dense core granules.
enlarge picture
Merkel cell carcinoma

Merkel cell carcinoma

A highly aggressive skin tumour, usually of the head and neck, which is most common in the elderly, and 13-fold more common in patients with HIV-1. Merkel cell polyomavirus is clonally integrated at various sites in the genome of most Merkel cell carcinomas.

Actinic keratoses, Bowen's disease, squamous cell carcinoma, basal cell carcinoma.
Small blue-cell tumours—e.g., leukaemia, acute lymphoblastic lymphoma, granulocytic sarcoma, NK/T-cell lymphoma, and metastatic small cell carcinoma from the lung or elsewhere.
3-year survival: 68% female, 36% male.

Poor prognosticators
> 30 mm tumour, stage II+, lack of inflammation, Ki-67 (cell proliferation) index of > 50%.

Wide excision, prophylactic lymph node dissection, radiation therapy, chemotherapy.

Merkel cell carcinoma

Cutaneous neuroendocrine carcinoma A highly malignant skin tumor, usually head & neck, most common in the elderly Prognosis Poor, 3-yr survival 68% ♀, 36% ♂ Treatment Wide excision, prophylactic LN dissection, RT, chemotherapy

Mer·kel cell car·ci·no·ma

(mĕr'kĕl sel kahr'si-nō'mă)
Rare and highly aggressive skin cancer, with lesions that develop on or just below the skin that are usually found on sun-exposed body areas; appear as painless, firm nodules or tumors; metastasize quickly and spread to other parts of the body, tending toward the regional lymph nodes. Twice as common in older men.
References in periodicals archive ?
A new virus, Merkel cell polyomavirus (MCPyV), recently was discovered in humans with Merkel cell carcinoma (MCC), a relatively rare, aggressive primary cutaneous neuroendocrine carcinoma.

Full browser ?