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cutaneous T cell lymphoma |
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cutaneous T cell lymphoma Mycosis fungoides Oncology A heterogeneous group of relatively uncommon NHLs, which first appear on the skin Epidemiology ±1000 cases occur/yr, US, affecting ages 50-60; ♂:♀ ratio, 2:1;
black:white, 2:1 Clinical Long–4-10 yrs Hx of eczematous rashes, which may evolve to parapsoriasis en plaque or poikiloderma atrophicans vasculare Pathology Epidermotropism, paracortical proliferation in lymph nodes, periarterial
proliferation in spleen; aggregates of epithelioid cells, prominent vascular channels, BM involvement Management Nitrogen mustard, BCNU, PUVA therapy, RT Response rate 80% if T1; 30–60% if T2; 20% if T3. See Redman syndrome, Sézary
syndrome. |
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In the past three years, Edelson and his colleagues have treated 11 patients suffering from cutaneous T cell lymphoma. |
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