Cushing syndrome


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Cush·ing syn·drome

(kush'ing),
a disorder resulting from increased adrenocortical secretion of cortisol (giving clinical picture of Cushing disease), due to any one of several sources: ACTH-dependent adrenocortical hyperplasia or tumor, ectopic ACTH-secreting tumor, or excessive administrations of steroids; characterized by trunkal obesity, moon face, acne, abdominal striae, hypertension, decreased carbohydrate tolerance, protein catabolism, psychiatric disturbances, and osteoporosis, amenorrhea, and hirsutism in females; when associated with an ACTH-producing adenoma, called Cushing disease.
Synonym(s): Cushing basophilism

Cushing syndrome

or

Cushing's syndrome

n.
A group of symptoms, including a puffy face, fat accumulation around the torso, fat loss from legs and arms, and easy bruising, resulting from elevated levels of cortisol in the bloodstream that are caused either by excess production of the hormone ACTH, as from an adrenal or pituitary tumor, or by administration of high doses of corticosteroid hormones. Cushing syndrome caused by a pituitary tumor is called Cushing disease.

Cushing syndrome

Hypercortisolism A condition characterized by excess corticosteroids, due either to an hypersecretion of cortisol by a hyperfunctioning or neoplastic adrenal cortex, or due to exogenous corticosteroids Etiology Exogenous coticosteroid administration; less commonly, pituitary hyperplasia, adenomas, or cancer Clinical Amenorrhea, hirsutism, HTN, impotence, muscular wasting, skin atrophy, neuropsychiatric dysfunction, osteoporosis, truncal–central obesity, weight gain–water retention, moon face, weakness, fatigue, backache, headache, ↑ thirst, ↑ urination, DM, osteoporosis Lab Hypersecretion of cortisol, loss of the usual circadian rhythm of ACTH and cortisol, and loss of suppressibility of cortisol production by administration of dexamethasone; ↑ adrenal androgens suppresses pituitary output of LH and FSH and causes ↓ sperm production or ovulatory failure Management Surgical excision if tumor is ID'd. See Dexamethasone suppression test, Ectopic hormone syndrome. Cf Pseudo-Cushing syndrome.

Cush·ing syn·drome

(kush'ing sin'drōm)
A disorder resulting from increased adrenocortical secretion of cortisol (giving a clinical picture of Cushing disease), due to any one of several sources: adrenocorticotropic (ACTH)-dependent adrenocortical hyperplasia or tumor, ectopic ACTH-secreting tumor, or excessive administration of steroids; characterized by truncal obesity, moon face, acne, abdominal striae, hypertension, decreased carbohydrate tolerance, protein catabolism, psychiatric disturbances, and osteoporosis, amenorrhea, and hirsutism in females; when associated with an ACTH-producing adenoma, called Cushing disease.
Synonym(s): Cushing basophilism.

Cushing,

Harvey Williams, U.S. neurosurgeon, 1869-1939.
Cushing basophilism - Synonym(s): Cushing syndrome
Cushing bone rongeur
Cushing brain depressor
Cushing brain forceps
Cushing brain spatula
Cushing cranial bur
Cushing cranial rongeur forceps
Cushing disease - adrenal hyperplasia (Cushing syndrome) caused by an ACTH-secreting basophil adenoma of the pituitary. Synonym(s): Cushing pituitary basophilism
Cushing dressing forceps
Cushing dural hook
Cushing dural hook knife
Cushing effect - Synonym(s): Cushing phenomenon
Cushing Gigli-saw guide
Cushing nerve retractor
Cushing perforator
Cushing perforator drill
Cushing periosteal elevator
Cushing phenomenon - a rise in systemic blood pressure when the intracranial pressure acutely increases. Synonym(s): Cushing effect; Cushing response
Cushing pituitary basophilism - Synonym(s): Cushing disease
Cushing response - Synonym(s): Cushing phenomenon
Cushing self-retaining retractor
Cushing straight retractor
Cushing syndrome - a disorder resulting from increased adrenocortical secretion of cortisol. Synonym(s): adrenalism; Cushing basophilism; Gallais syndrome; Itsenko-Cushing syndrome
Cushing syndrome medicamentosus - a variable number of the signs and symptoms of Cushing syndrome.
Cushing ulcer
Itsenko-Cushing syndrome - Synonym(s): Cushing syndrome

Cush·ing syn·drome

(kush'ing sin'drōm)
Disorder resulting from increased adrenocortical secretion of cortisol.
References in periodicals archive ?
Although all cases of Cushing syndrome result from prolonged exposure to cortisol, the clinical manifestation varies widely (6).
4) We herein report a case of subcutaneous emphysema and pneumomediastinum resulting from necrotizing fasciitis and pyomyositis over the right arm of a woman with diabetes mellitus and iatrogenic Cushing syndrome.
The performance of this test is consistent with preoperative studies demonstrating suboptimal specificity for the diagnosis of Cushing syndrome (3-5).
Based on a population study, the annual incidence of endogenous Cushing syndrome is estimated to be approximately 1.
It is important to analyze diurnal rhythm; some people have a constant secretion of cortisol and can have subclinical Cushing syndrome.
Finally, we analyzed another tablet, of unknown origin, that had been retrieved from a patient who had undetectable serum cortisol concentrations but exhibited symptoms of Cushing syndrome.
However, the high reliability of using 24-h urinary cortisol excretion for the diagnosis of Cushing syndrome implies that urinary excretion of cortisol is relatively unaffected by renal function.
This makes it a suitable test for daily laboratory and clinical use, as recently advocated for the diagnosis of Cushing syndrome (9).
The measurement of salivary cortisol is emerging as the simplest approach in the diagnosis of Cushing syndrome (1-3).
The last group (6) showed that of four commercial antibodies tested in samples from 20 patients, including patients with Cushing syndrome, obesity, and pregnancy, two appeared to be much less specific than the three transcortins (human, dog, and horse).
The four endocrine disorders selected for these test strategy paradigms are Cushing syndrome, pheochromocytoma, primary aldosteronism, and hypercalcemia.
Measurement of 24-h urinary free cortisol (UFC) provides the most sensitive and specific diagnostic information for adrenal malfunctions, especially for Cushing syndrome [1, 2].