Cushing's disease


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Related to Cushing's disease: Cushing's syndrome, cortisol, Addison's disease

Cushing's disease

 [koosh´ingz]
Cushing's syndrome in which the hyperadrenocorticism is secondary to excessive pituitary excretion of adrenocorticotropic hormone.

Cushing's disease

[koo͡sh′ingz]
Etymology: Harvey W. Cushing
a metabolic disorder characterized by abnormally increased secretion of adrenocortical steroids, particularly cortisol, caused by increased amounts of adrenocorticotropic hormone (ACTH) secreted by the pituitary, such as by a pituitary adenoma. Excess adrenocortical hormones result in accumulations of fat on the abdomen, chest, upper back, and face and occurrence of edema, hyperglycemia, increased gluconeogenesis, muscle weakness, purplish striae on the skin, decreased immunity to infection, osteoporosis with susceptibility to bone fractures, acne, and facial hair growth in women. Diabetes mellitus may become a chronic condition. Therapy is aimed at removal or destruction of ACTH secreting tissue, most commonly by surgical or radiological procedures. The adrenal glands may be totally or subtotally removed and pharmacological preparations of adrenal steroids administered. Also called hyperadrenalism. Compare Cushing's syndrome.

Cushing's disease

see syndrome, Cushing's

Cushing's disease

hyperadrenocorticism secondary to excessive pituitary excretion of adrenocorticotropic hormone; based on the original description by Dr. Harvey Cushing of humans with pituitary tumors, described as basophil adenomas of the pars distalis; now taken to include also the more common corticotroph adenomas (cushing-like disease). Called also pituitary-dependent hyperadrenocorticism.
References in periodicals archive ?
We report an unusual case of a 79 year old elderly patient presenting with subclinical Cushing's disease caused by pituitary macroadenoma (ACTHoma) found incidentally.
Approval was based on a phase III study of 162 people with Cushing's disease, with mean urinary cortisol levels at least 1.
Cushing's disease most commonly affects adults as young as 20 to 50 years and affects women three times more often than men.
Complex diseases such as Cushing's disease develop in a slow insidious manner that makes them especially hard to diagnose in their early stages.
She had died of an acute bleed in a pituitary gland tumour which was the cause of Cushing's Disease.
Katelyn faced a greater challenge than most of the other girls: At 16, she was diagnosed with Cushing's disease, which is caused by a tumor on the pituitary gland.
They found out he was suffering from hyperthyroidism and Cushing's Disease - then sorted him right out.
Mr Page expects the US launch of Dechra's drug Vetoryl, a treatment for Cushing's disease in dogs, to pay for itself from the outset.
Yosipovitch because of concern that the stretch marks were a manifestation of Cushing's disease.
The company has made considerable progress in advancing its late stage HIV drug SP-01A through two Phase II monotherapy trials, advancing its promising memory restoring Alzheimer's drug in preparation for Phase I human trials and its stress hormone modulating drug for high cortisol Cushing's disease.
All participants were screened for stimulated or deficient steroid secretion due to Cushing's disease, adrenal tumours, Addison's disease and adrenocorticotropic hormone deficiency disease.
To emphasize further distinguishing pituitary-dependent Cushing's disease from pseudo-Cushing's states presents a diagnostic challenge.