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Cushing's syndrome in which the hyperadrenocorticism is secondary to excessive pituitary excretion of adrenocorticotropic hormone.
Etymology: Harvey W. Cushing
a metabolic disorder characterized by abnormally increased secretion of adrenocortical steroids, particularly cortisol, caused by increased amounts of adrenocorticotropic hormone (ACTH) secreted by the pituitary, such as by a pituitary adenoma. Excess adrenocortical hormones result in accumulations of fat on the abdomen, chest, upper back, and face and occurrence of edema, hyperglycemia, increased gluconeogenesis, muscle weakness, purplish striae on the skin, decreased immunity to infection, osteoporosis with susceptibility to bone fractures, acne, and facial hair growth in women. Diabetes mellitus may become a chronic condition. Therapy is aimed at removal or destruction of ACTH secreting tissue, most commonly by surgical or radiological procedures. The adrenal glands may be totally or subtotally removed and pharmacological preparations of adrenal steroids administered. Also called hyperadrenalism. Compare Cushing's syndrome.
hyperadrenocorticism secondary to excessive pituitary excretion of adrenocorticotropic hormone; based on the original description by Dr. Harvey Cushing of humans with pituitary tumors, described as basophil adenomas of the pars distalis; now taken to include also the more common corticotroph adenomas (cushing-like disease). Called also pituitary-dependent hyperadrenocorticism.