Cushing's disease


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Related to Cushing's disease: Cushing's syndrome, cortisol, Addison's disease

Cushing's disease

 [koosh´ingz]
Cushing's syndrome in which the hyperadrenocorticism is secondary to excessive pituitary excretion of adrenocorticotropic hormone.

Cushing's disease

[koo͡sh′ingz]
Etymology: Harvey W. Cushing
a metabolic disorder characterized by abnormally increased secretion of adrenocortical steroids, particularly cortisol, caused by increased amounts of adrenocorticotropic hormone (ACTH) secreted by the pituitary, such as by a pituitary adenoma. Excess adrenocortical hormones result in accumulations of fat on the abdomen, chest, upper back, and face and occurrence of edema, hyperglycemia, increased gluconeogenesis, muscle weakness, purplish striae on the skin, decreased immunity to infection, osteoporosis with susceptibility to bone fractures, acne, and facial hair growth in women. Diabetes mellitus may become a chronic condition. Therapy is aimed at removal or destruction of ACTH secreting tissue, most commonly by surgical or radiological procedures. The adrenal glands may be totally or subtotally removed and pharmacological preparations of adrenal steroids administered. Also called hyperadrenalism. Compare Cushing's syndrome.

Cushing's disease

see syndrome, Cushing's

Cushing's disease

hyperadrenocorticism secondary to excessive pituitary excretion of adrenocorticotropic hormone; based on the original description by Dr. Harvey Cushing of humans with pituitary tumors, described as basophil adenomas of the pars distalis; now taken to include also the more common corticotroph adenomas (cushing-like disease). Called also pituitary-dependent hyperadrenocorticism.
References in periodicals archive ?
ACTHomas with Cushing's disease represent 10-15% of pituitary tumors.
Reflecting the panel's recommendations to further study the long-term adverse effects of hyperglycemia and diabetes associated with the drug after approval, the FDA is requiring the company to conduct three postmarketing studies: a study that evaluates the management of hyperglycemia in treated patients; a long-term registry study of people with Cushing's disease treated with the drug; and a safety study that will monitor reports of serious hyperglycemia, acute liver injury, and adrenal insufficiency in patients treated with pasireotide.
Patients with Cushing's disease may suffer from debilitating manifestations, and there are many serious health complications associated with the disease," said Mary Andrews, CEO and Co-Founder of the US non-profit, The MAGIC Foundation.
Even though this patient was on corticosteroids for only 15 months before this neurological presentation, she had already manifested signs of idiopathic Cushing's disease.
Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure.
Undetectable urinary free cortisol concentrations in a case of Cushing's disease.
Horses are living longer than ever before, and with that rise in longevity has come an increase in the reported cases of Cushing's disease.
Mifepristone, which is used to induce abortions but was originally designed as treatment for Cushing's disease, has achieved rapid reversal of symptoms in some 30 psychotically depressed patients, ostensibly by blocking cortisol receptors.
By virtue of its tissue-selective toxicity, o,p'-DDD is currently used as an adrenocorticolytic drug to treat adrenocortical carcinoma and Cushing's disease (5).
It had earlier won approval for use in canine Cushing's disease, a hormonal imbalance, in both Canada and the United States.
Physicians should be alert when performing plasma cortisol blood tests in Addison's disease patients (who have adrenal hypofunction) or Cushing's disease patients (who also have adrenal hyperfunction) because the time of day when administered can be significant.
Several therapies are available to treat the ACTH-secreting pituitary adenomas of Cushing's disease.