Currarino syndrome


Also found in: Wikipedia.

Currarino syndrome

An autosomal dominant condition (OMIM:176450) characterised by sacral agenesis, a presacral mass and anorectal malformation, variably accompanied by anterior meningocele or a presacral teratoma.

Molecular pathology
Defects in MNX1/HLXB9, which encodes a nuclear transcription factor involved in pancreas development and function, cause Currarino syndrome.

Currarino,

Guido, Italian-born U.S. radiologist, 1920–. U.S. radiologist born in Italy, 1920–.
Currarino triad - complex of anococcygeal congenital anomalies. Synonym(s): Currarino syndrome
Currarino-Silverman syndrome - growth abnormality of the sternum. Synonym(s): Silverman syndrome
Currarino syndrome - Synonym(s): Currarino triad
References in periodicals archive ?
The Currarino syndrome (C5; OMIM 176450) has been described as a triad of partial sacral agenesis with intact first sacral vertebra (sickle-shaped sacrum), presacral mass, and anorectal malformations (1-3).
HLXB9 and sacral agenesis and the Currarino syndrome.
Autosomal dominant sacral agenesis: Currarino syndrome.
Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene.
Involvement of the HLXB9 homeobox gene in Currarino syndrome.