poractant alfa

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poractant alfa

 [por-ak´tant al´fah]
an extract of porcine lung surfactant administered by instillation via the endotracheal tube in treatment of respiratory distress syndrome of the newborn.

poractant alfa

/por·ac·tant al·fa/ (por-ak´tant al´fah) an extract of porcine lung surfactant used in the treatment of respiratory distress syndrome of the newborn.

poractant alfa

a lung surfactant extract.
indication It is used in the treatment (rescue) of respiratory distress syndrome in premature infants.
contraindication None is currently known.
adverse effects Concurrent illnesses that have occurred during treatment with this drug include pulmonary air leaks, pulmonary interstitial emphysema, apnea, pulmonary hemorrhage, patent ductus arteriosus, intracranial hemorrhage, severe intracranial hemorrhage, necrotizing enterocolitis, posttreatment sepsis, and posttreatment infection. Adverse effects include bradycardia, oxygen desaturation, pallor, vasoconstriction, hypotension, and hypertension.
References in periodicals archive ?
Curosurf is a natural surfactant obtained from pig lungs, containing almost exclusively phospholipids, in particular phosphatidylcholine (about 70% of the total phospholipid) and approximately 1% hydrophobic proteins with molecular weight SP - B (surfactant protein B) and SP - C (surfactant protein C).
In order to assist prevention of high infant mortality, Help the Children - SKD has decided to grant 775 Curosurf packages.
Infants treated with SURFAXIN demonstrated a significantly lower reintubation rate compared with infants treated with animal-derived surfactants Curosurf (33 percent vs.
In addition, Chiesi is the licensor of two of Cornerstone's key products: Curosurf and Bethkis.
The transaction led to two important events: Cornerstone was conferred the responsibility for distributing Curosurf in USA and as a result, Chiesi made its direct entry into the American market.
The biological surfactant preparation Curosurf (poractant alfa) was derived from minced porcine lung extracts, and its indications followed similar risk profiles as noted in the biologicals above.
In 2000, a randomized, comparison study of prophylactic use of lung surfactants in the UK between a pumactant (a synthetic surfactant used exclusively in the UK) and Curosurf (poractant alfa) was halted half way through because of a mortality difference.
44 - completely denatured alcohol absolute- Problem # 33 - Means of contrast- Task number from 15 to 32 and 34, 39, 40, 41, 42, 43, 50-54 - Other medicaments include Acylovir, Paracetamol, Propofol, POSACONAZOLE, Palivizumab, Omeprazole, albumin, antithrombin, Etanercept, Kaspofugina, Abelcet, Imatybin, Bridion, Interferon, Nivestim, Botulinum toxin, Caphosol, Curosurf, Sevofluran, Desfluran, Human Immunoglobulin, Modulen, Peptamen, Ferbini, PreNAN, NAN PRO, Mycafungina, Peginterferonum, deferasirox, AmBisome, etc.
Another study it found no difference between Surfaxin and Curosurf.
Overall, CUROSURF treatment for RDS was associated with a significantly reduced likelihood of death compared to Infasurf, and a trend toward reduced mortality when compared with Survanta.
Infants treated with SURFAXIN demonstrated a significantly lower reintubation rate compared with those infants treated with animal-derived surfactants Curosurf (33 percent vs.
These data also suggest that Curosurf offers a rapid onset of action and requires fewer doses than Survanta.