warfarin (redirected from Cumadin)

warfarin /war·fa·rin/ (wor´fah-rin) a synthetic coumarinanticoagulant administered as the sodium salt; it is also used as a rodenticide, causing fatal hemorrhaging in any mammal consuming a sufficient dose.

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Warfarin

A drug given to control the formation of blood clots. The PT test can be used to monitor patients being treated with warfarin.

Mentioned in: Prothrombin Time, Puerperal Infection

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warfarin

a coumarin compound used as an anticoagulant in humans and as a rodenticide, with serious toxicity implications for all species. It is readily absorbed from the intestinal tract and acts to inhibit the reduction of oxidized vitamin K, resulting in a depletion of active vitamin K that is required for carboxylation of coagulation factors VII, IX, X and II.

Accidental poisoning in all species causes massive, spontaneous hemorrhage and death due to anemia. Less severe cases often show pulmonary hemorrhage. In pigs it is the legs that are affected preferentially and in dogs hemorrhage into the anterior mediastinum and lungs is common. Vitamin K is the specific antidote.

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warfarin

Coumadin Hematology An anticoagulant that inhibits synthesis of liver-dependent coagulation factors–the prothrombin complex, factors II, VII, IX and X, which are formed by γ-carboxylation of precursor proteins Indications Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute MI; warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 secs; its activity is ↑ by phenylbutazone, clofibrate–by outcompeting with warfarin for plasma protein binding sites and ↓ by barbiturates, which stimulate hepatic metabolism. See Superwarfarin. Cf Heparin.

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Patient discussion about Cumadin.

Q. how medications effect me side effects warfarin,s effect what does I and R mean i have my I and R each week, what is it,s function..........

A. It is the INR or International Normalized Ratio. It is essential a measurement of how thin your blood is from taking the warfarin. Depending on why you are taking the warfarin the number is usually supposed to be between 2-3.5. I hope this helps.