are the major component of fiber cells, which form the eyes' lenses, and the unique properties of these cells make them particularly susceptible to damage, said Jason Gestwicki, PhD, associate professor of pharmaceutical chemistry at UCSF and co-senior author of a paper on the new research, most of which was undertaken in Gestwicki's laboratory at the U-M Life Sciences Institute.
In order for our lenses to function well, this permanent, finite reservoir of crystallins
must maintain both the transparency of fiber cells and their flexibility, as the eyes muscles constantly stretch and relax the lens to allow us to focus on objects at different distances.
Two extra proteins like PB1 crystallin
and aldehyde dehydrogenase1A1 (ALDH1A1) were also identified by Western blotting using monoclonal antibodies.
must exist for a long time in high concentration.
09:00 DIFFERENTIAL EXPRESSION OF ALPHA CRYSTALLIN
IN THE ZEBRAFISH, DANIO RERIO.
Tip of an Iceberg of Guardian Amyloids Including Crystallins
, Prion, Tau, Amyloid Beta and Others.
Elevated expression of a A- and a-B crystallins
in streptozotocin-induced diabetic rat.
In the lens, cross-linking between crystallins
is associated with cataract.
PURPOSE: Senile cataracts are associated with oxidation, fragmentation, cross-linking, insolubilization, and yellow pigmentation of lens crystallins
Changes in constituents of the chemome also appear with age; some modified amino acids accumulate naturally with age in long-lived proteins, such as crystallins
and collagens, and the rate of their accumulation is accelerated in chronic disease (3).
The alpha, beta, and gamma crystallins
represent the major proteins found in the vertebrate eye lens.
They confirmed this role, which had been suggested by previous, preliminary research, by comparing the amino acid sequences of the crystallins
with the sequences found in several enzymes.