cryoglobulinemia /cryo·glob·u·lin·emia/ (-glob″u-lin-e´me-ah) the presence in the blood of cryoglobulin,which is precipitated in the microvasculature on exposure to cold.
Cryoglobulinemia
cryoglobulinemia
cryoglobulinemia
cry·o·glob·u·li·ne·mi·a (kr   -gl by -l-n  m-)n. The presence of abnormal quantities of cryoglobulin in the blood plasma. |
Cryoglobulinemia
Condition in which protein in the blood forms particles in the cold, blocking blood vessels and leading to pain and numbness of the extremities.
Mentioned in: Multiple Myeloma, Waldenström's Macroglobulinemia
cryoglobulinemia
[krī′ōglob′yoo͡linē′mē·ə]
Etymology: Gk, kryos + L, globulus, small sphere; Gk, haima, blood
the presence of cryoglobulins in the blood. Presence of cryoglobulins may be associated with Waldenström's macroglobulinemia, hepatitis C, multiple myeloma, and leukemia.
cryoglobulinemia
the presence of cryoglobulin in the blood, which is precipitated in the microvasculature upon exposure to cold.
cryoglobulinemia
Primary cryoglobulinemia Hematology A condition caused by proteins that precipitate in vivo on cooling of acral parts, which are often associated with immune complex-related disease; cryoglobulinemia has been divided into 3
clinical forms Clinical Pain, cyanosis, arthralgias, vascular purpuras, cold intolerance, HTN, CHF Lab ↓ C4 and other complement proteins
Cryoglobulinemia
Type I Monoclonal cryoglobulinemia Underlying disease is often malignant; IgG (malignant myeloma), IgM macroglobulinemia or lymphoma/CLL, rarely others (eg IgA nephropathy), benign monoclonal gammopathy
Type II Poly-monoclonal cryoglobulinemia A complex of immunoglobulins, eg mixed IgM-IgG, G-G, A-G or other combinations that may be associated with lymphoreticular disease or connective tissue disease (rheumatoid arthritis, Sjögren
syndrome, mixed essential cryoglobulinemia)
Type III Mixed polyclonal-polyclonal cryoglobulinemia Mixed IgG & IgM, ± IgA, due to rheumatoid arthritis, SLE, Sjögren syndrome, EBV, CMV, subacute bacterial infections, poststreptococcal, crescentic and
membranoproliferative glomerulonephritides, DM, chronic hepatitis, biliary cirrhosis
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