cryoglobulinemia

(redirected from Cryoglobulinaemia)
Also found in: Wikipedia.

cryoglobulinemia

 [kri″o-glob″u-lin-e´me-ah]
the presence of cryoglobulin in the blood, associated with a variety of clinical manifestations including Raynaud's phenomenon, vascular purpura, cold urticaria, necrosis of extremities, bleeding disorders, vasculitis, arthralgia, neurologic manifestations, hepatosplenomegaly, and glomerulonephritis.

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă),
The presence of abnormal quantities of cryoglobulin in the blood plasma.

cryoglobulinemia

/cryo·glob·u·lin·emia/ (-glob″u-lin-e´me-ah) the presence in the blood of cryoglobulin,which is precipitated in the microvasculature on exposure to cold.

cryoglobulinemia

[krī′ōglob′yoo͡linē′mē·ə]
Etymology: Gk, kryos + L, globulus, small sphere; Gk, haima, blood
the presence of cryoglobulins in the blood. Presence of cryoglobulins may be associated with a variety of clinical disorders including Waldenström's macroglobulinemia, hepatitis C, multiple myeloma, and leukemia.

cryoglobulinemia

Primary cryoglobulinemia Hematology A condition caused by proteins that precipitate in vivo on cooling of acral parts, which are often associated with immune complex-related disease; cryoglobulinemia has been divided into 3 clinical forms Clinical Pain, cyanosis, arthralgias, vascular purpuras, cold intolerance, HTN, CHF Lab ↓ C4 and other complement proteins
Cryoglobulinemia
Type I Monoclonal cryoglobulinemia Underlying disease is often malignant; IgG (malignant myeloma), IgM macroglobulinemia or lymphoma/CLL, rarely others (eg IgA nephropathy), benign monoclonal gammopathy
Type II Poly-monoclonal cryoglobulinemia A complex of immunoglobulins, eg mixed IgM-IgG, G-G, A-G or other combinations that may be associated with lymphoreticular disease or connective tissue disease (rheumatoid arthritis, Sjögren syndrome, mixed essential cryoglobulinemia)
Type III Mixed polyclonal-polyclonal cryoglobulinemia Mixed IgG & IgM, ± IgA, due to rheumatoid arthritis, SLE, Sjögren syndrome, EBV, CMV, subacute bacterial infections, poststreptococcal, crescentic and membranoproliferative glomerulonephritides, DM, chronic hepatitis, biliary cirrhosis

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă)
The presence of abnormal quantities of cryoglobulin in blood plasma.
Synonym(s): cryoglobulinaemia.

Cryoglobulinemia

Condition in which protein in the blood forms particles in the cold, blocking blood vessels and leading to pain and numbness of the extremities.

cryoglobulinemia

the presence of cryoglobulin in the blood, which is precipitated in the microvasculature upon exposure to cold.
References in periodicals archive ?
Table 1 Differential diagnosis of digital ischaemia post-cardiac surgery Aetiology Pathology and clinical examples Vessel wall Atherosclerosis Vasculitis: drug induced, cryoglobulinaemia, Takayasu's arteritis, Wegener's granulomatosis, Reynaud's syndrome, systemic sclerosis, mixed connective tissue disease Embolism Cardiac source Proximal arterial aneurysm Thrombosis Atherosclerosis Arterial reconstruction Arterial catheter injury Arterial dissection Antiphospholipid syndrome Thrombosic thrombocytopenia purpura HITTS Disseminated intravascular coagulation Trauma/physical Drugs, e.
EAC has been associated with many different entities, including infections, food allergy and drug reactions, polycythemia vera, cryoglobulinaemia, myelodysplastic syndrome, hypereosinophilic syndrome, hyperthyroidism, autoimmune thyroidities, hepatic diseases, pregnancy and malignant neoplasms (2).
Coeliac disease, vasculitis, and cryoglobulinaemia.
paraproteinaemia and dysproteinaemias--multiple myeloma, cryoglobulinaemia
Non-enveloped HCV core rotein as constitutive antigen of cold-precipitable immune complexes in type ii mixed cryoglobulinaemia.
Increased serum concentrations of soluble HLA-class I antigens in hepatitis C virus related mixed cryoglobulinaemia.
High prevalence of peripheral neuropathy in hepatitis C virus infected patients with symptomatic and asymptomatic cryoglobulinaemia.
Prevalence and clinical features of cryoglobulinaemia in multitransfused beta-thalassaemia patients.
coli-associated, familial, idiopathic) Thrombotic thrombocytopenic purpura (familial, recurrent, idiopathic) Malignant hypertension Medication (cyclosporine A, tacrolimus, mitomycin, ticlopidine, clopidogrel, etc) Post organ/haematopoietic cell transplantation Disseminated intravascular coagulation Sepsis Malignancy Pre-eclampsia /eclampsia, HELLP syndrome Systemic vasculitis (SLE, scleroderma, cryoglobulinaemia, etc) E.
Bronchoalveolar lavage in mixed cryoglobulinaemia associated with hepatitis C virus.