cryoglobulinemia

(redirected from Cryoglobulinaemia)

cryoglobulinemia

 [kri″o-glob″u-lin-e´me-ah]
the presence of cryoglobulin in the blood, associated with a variety of clinical manifestations including Raynaud's phenomenon, vascular purpura, cold urticaria, necrosis of extremities, bleeding disorders, vasculitis, arthralgia, neurologic manifestations, hepatosplenomegaly, and glomerulonephritis.

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă),
The presence of abnormal quantities of cryoglobulin in the blood plasma.

cryoglobulinemia

/cryo·glob·u·lin·emia/ (-glob″u-lin-e´me-ah) the presence in the blood of cryoglobulin,which is precipitated in the microvasculature on exposure to cold.

cryoglobulinemia

[krī′ōglob′yoo͡linē′mē·ə]
Etymology: Gk, kryos + L, globulus, small sphere; Gk, haima, blood
the presence of cryoglobulins in the blood. Presence of cryoglobulins may be associated with a variety of clinical disorders including Waldenström's macroglobulinemia, hepatitis C, multiple myeloma, and leukemia.

cryoglobulinemia

Primary cryoglobulinemia Hematology A condition caused by proteins that precipitate in vivo on cooling of acral parts, which are often associated with immune complex-related disease; cryoglobulinemia has been divided into 3 clinical forms Clinical Pain, cyanosis, arthralgias, vascular purpuras, cold intolerance, HTN, CHF Lab ↓ C4 and other complement proteins
Cryoglobulinemia
Type I Monoclonal cryoglobulinemia Underlying disease is often malignant; IgG (malignant myeloma), IgM macroglobulinemia or lymphoma/CLL, rarely others (eg IgA nephropathy), benign monoclonal gammopathy
Type II Poly-monoclonal cryoglobulinemia A complex of immunoglobulins, eg mixed IgM-IgG, G-G, A-G or other combinations that may be associated with lymphoreticular disease or connective tissue disease (rheumatoid arthritis, Sjögren syndrome, mixed essential cryoglobulinemia)
Type III Mixed polyclonal-polyclonal cryoglobulinemia Mixed IgG & IgM, ± IgA, due to rheumatoid arthritis, SLE, Sjögren syndrome, EBV, CMV, subacute bacterial infections, poststreptococcal, crescentic and membranoproliferative glomerulonephritides, DM, chronic hepatitis, biliary cirrhosis

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă)
The presence of abnormal quantities of cryoglobulin in blood plasma.
Synonym(s): cryoglobulinaemia.

Cryoglobulinemia

Condition in which protein in the blood forms particles in the cold, blocking blood vessels and leading to pain and numbness of the extremities.

cryoglobulinemia

the presence of cryoglobulin in the blood, which is precipitated in the microvasculature upon exposure to cold.
References in periodicals archive ?
Erythema elevatum diutinum, cryoglobulinaemia, and fixed urticaria on cooling.
High prevalence of peripheral neuropathy in hepatitis C virus infected patients with symptomatic and asymptomatic cryoglobulinaemia.
Gross, "Mixed cryoglobulinaemia, glomerulonephritis, and ANCA: essential cryoglobulinaemic vasculitis or ANCA-associated vasculitis?
7] Subepithelial deposits are the characteristic all found in acute PSGN and may occur in glomerulonephritis due to bacterial endocarditis, systemic lupus erythematosus and cryoglobulinaemia.
Participants were excluded from the study if they had impaired healing such as diabetes or peripheral vascular disease, were immunosuppressed or were taking immunosuppressant drugs such as oral corticosteroids, had neuropathy, were receiving renal dialysis, had cold intolerence such as Raynaud's syndrome or had conditions such as cryoglobulinaemia, cryofibrinogenaemia, collagen or autoimmune disease.
Surrogate markers of B cell non-Hodgkin's lymphoma in patients with hepatitis C virus-related cryoglobulinaemia vasculitis.
Epidemiology, clinical spectrum and prognostic value of mixed cryoglobulinaemia in hepatitis C virus patients: a prospective study.
Table 1 Differential diagnosis of digital ischaemia post-cardiac surgery Aetiology Pathology and clinical examples Vessel wall Atherosclerosis Vasculitis: drug induced, cryoglobulinaemia, Takayasu's arteritis, Wegener's granulomatosis, Reynaud's syndrome, systemic sclerosis, mixed connective tissue disease Embolism Cardiac source Proximal arterial aneurysm Thrombosis Atherosclerosis Arterial reconstruction Arterial catheter injury Arterial dissection Antiphospholipid syndrome Thrombosic thrombocytopenia purpura HITTS Disseminated intravascular coagulation Trauma/physical Drugs, e.
In hepatitis C cryoglobulinaemia (an example of an infectious cause of IC disease) it is important to block B cells but also to remove antigen by treating the infection.
EAC has been associated with many different entities, including infections, food allergy and drug reactions, polycythemia vera, cryoglobulinaemia, myelodysplastic syndrome, hypereosinophilic syndrome, hyperthyroidism, autoimmune thyroidities, hepatic diseases, pregnancy and malignant neoplasms (2).
HCV infection is also associated with cryoglobulinaemia,6 non-Hodgkin's lymphoma 7,8 and glomerulonephritis.
Bortezomib for the treatment of refractory Type-1 cryoglobulinaemia.