Crouzon syndrome


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Related to Crouzon syndrome: Pfeiffer syndrome, Treacher Collins syndrome

Crou·zon syn·drome

(krŭ-zŏn[h]'), [MIM*123500]
craniosynostosis with broad forehead, ocular hypertelorism, exophthalmos, beaked nose, and hypoplasia of the maxilla; autosomal dominant inheritance, caused by mutation in the fibroblast growth factor receptor 2 gene (FGFR2) on chromosome 10q. Crouzon syndrome with acanthosis nigricans is due to mutation in the fibroblast growth factor receptor 3 gene (FGFR3) on 4p.

Crouzon syndrome

(kro͞o-zŏn′, -zôN′)
n.
A genetic disorder characterized by premature closure of one or more cranial sutures, resulting in craniofacial abnormalities such as oxycephaly, widely spaced, protruding eyes, and hypoplasia of the maxilla. Also called craniofacial dysostosis.

Crouzon syndrome

An autosomal dominant condition (OMIM:123500) characterised by craniosynostosis causing secondary defects of facial bones and structures, including hypertelorism, exophthalmos and external strabismus, parrot-beaked nose, short upper lip, hypoplastic maxilla, and a relative mandibular prognathism.

Molecular pathology
Mutations of FGFR2 cause Crouzon syndrome.

Crou·zon syn·drome

(krū-zōn[h]' sin'drōm)
Craniosynostosis with broad forehead, ocular hypertelorism, exophthalmos, beaked nose, and hypoplasia of the maxilla; associated with hearing loss.

Crou·zon syn·drome

(krū-zōn[h]' sin'drōm) [MIM*123500]
Craniosynostosis with broad forehead, ocular hypertelorism, exophthalmos, beaked nose, and hypoplasia of the maxilla.
References in periodicals archive ?
Dental and orthodontic management of patients with Apert and Crouzon syndromes.
Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2.
Crouzon Syndrome is caused by a problem with genes, and 50 per cent of the time is passed on through the father's sperm.
Mutations in the third immunoglobulin domain of the fibroblast growth factor receptor-2 gene in Crouzon syndrome.
THIS series, following children with complex medical conditions as they undergo pioneering treatment at London's Great Ormond Street Hospital, takes a look at a youngster with Crouzon syndrome.
He was given just a three per cent chance of survival after being diagnosed with Crouzon syndrome, which causes the brain and skull to fuse together.
DIFFERENTIAL DIAGNOSIS: Includes all other syndromes characterized by Acrocephalosyndactyly such as 1) crouzon syndrome 2) carpenter syndrome 3) Pfeiffer syndrome.
Brent, who has Tourette's syndrome, is planning to ask Challis to be his wife, while Steve, who has Crouzon syndrome, is also looking forward to proposing.
But when 38-year-old Beverley discovered her third child would be born with disfiguring Crouzon syndrome she was overwhelmed with fear and dreaded seeing her new baby for the first time.
Correction of infraorbital and malar deficiency using costal osteochondral graft along with orthognathic surgery in crouzon syndrome.