crossover trial

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crossover trial

A clinical trial design in which subjects act as their own control and are assigned to receive investigational product and controls in an order determined by randomisations, with a washout period between the two epochs.

crossover trial

A scientific study of a therapeutic agent in which participants are exposed in sequence to the putative cure and subsequently (or previously) to an inactive agent or an agent whose efficacy has been previously established. The participants cross over from one arm of the study to the other and serve as their own control group.

Participants in such trials are usually under the care of a team of physicians and nurses and are closely monitored, often with testing and examinations on a weekly basis. The clinical trial nurse or nurse research specialist has a broad variety of roles, depending on the nature of the investigation. The roles include recruiting and introducing patients to the trial, coordinating their care, gathering data about side effects and tolerance, and, frequently, serving as a principal or collaborative investigator. Trial planning and design, data interpretation and analysis, and assessments of toxicity are all elements of the work. Health insurers and managed care providers may place restrictions on clinical trial coverage. Many states have laws requiring insurers to pay for the routine costs of all or some clinical trials. Patient advocates work with researchers to make sure a clinical trial is relevant, as safe as possible, and accessible to the broadest variety of patients.

Synonym: crossover (2)
See also: trial
References in periodicals archive ?
In this double-blind, placebo-controlled, crossover study, each patient will also receive two different doses of nebulised salbutamol, a commonly used bronchodilator in these patients, and placebo.
This Phase II trial is a double-blind, randomized, placebo-controlled, crossover study in 48 adult patients with refractory chronic cough, including individuals with idiopathic pulmonary fibrosis, or IPF.
PLoS One reported the outcome of a double-blind, crossover study that found supplementation with chondroitin sulfate and glucosamine hydrochloride, a nutritional combination used to alleviate symptoms of arthritis, was associated with a reduction in C-reactive protein (CRP), a marker of inflammation.
Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebocontrolled crossover study.
Anne-Marie Chang and colleagues conducted a randomized, crossover study evaluating the impact of an e-book and a traditional book on sleep (PNAS 2014 Dec.
9% NaCl) solution (control treatment) were administered intramuscularly to kestrels in a masked randomized complete crossover study design.
A randomised, crossover study among 170 women in Durban, South Africa, assessed preference, safety, acceptability and function of three new female condoms (WC, FC2 and V-Amour) over time.
In one double-blind, placebo-controlled, crossover study, oxytocin was shown to improve emotion recognition, Bruno Averbeck, Ph.
1373) conducted a crossover study in Ottawa, Ontario, Canada, to examine the relationship between traffic pollution and acute changes in heart rate variability in 42 healthy nonsmoking men and women who were not exposed to tobacco smoke in the home and did not take medications for preexisting cardiovascular or respirator)' conditions.
A randomized crossover study was conducted between January 1 and December 31, 2009.
In this 12-week crossover study, patients (n=182) were randomized to receive either FOSRENOL or sevelamer for four weeks, and then switched to the alternative phosphate binder for the same period.
Capsimax Plus Blend was the subject of a recent double blind, randomized, placebo-controlled crossover study conducted by the Biophysics Laboratory, Department of Health and Exercise Science at the University of Oklahoma to research its effect on calorie burning in exercising individuals.