Crooke hyaline change

Crooke hy·a·line change

(kruk),
replacement of cytoplasmic granules of basophil cells of the anterior pituitary by homogeneous hyaline material; a characteristic finding in Cushing syndrome, but usually not present in the cells of a basophil adenoma.

Crooke hy·a·line change

(kruk hī'ă-lin chānj)
Replacement of cytoplasmic granules of basophil cells of the anterior pituitary by homogeneous hyaline material; a characteristic finding in Cushing syndrome, but usually not present in the cells of a basophil adenoma.

Crooke,

Arthur Carleton, English pathologist, 1905–.
Crooke granules - lumpy masses of basophilic material in the pituitary associated with Cushing disease or following the administration of ACTH.
Crooke hyaline change - replacement of cytoplasmic granules of basophil cells of the anterior pituitary by homogenous hyaline material. Synonym(s): Crooke hyaline degeneration
Crooke hyaline degeneration - Synonym(s): Crooke hyaline change
References in periodicals archive ?
In contrast, the documentation of Crooke hyaline change confirms the diagnosis of pathologic glucocorticoid excess that may have been cured by the surgery even if no adenoma is identified by the pathologist.