Like Abraxane, Paclical is free of Cremophor
EL, but unlike Abraxane, Paclical does not contain human albumin.
The clinical application of commercial paclitaxel injection (Taxol[R]) is, however, hampered in part by anaphylactic reactions related to Cremophor
EL, a surfactant used to improve the solubility of PTX (Nehate et al.
3 ml/kg BW of vehicle: ethanol 95%, Cremophor
EL, and sterile water for injections (1:1:8, v/v) from GD15 to post-natal day (PND) 20 every 5 days (a total of six injections/dam).
Charles Bennett of Northwestern's Feinberg School and Dennis Raisch of the University of New Mexico said the severe allergic reactions are believed to be caused by Cremophor
, the chemical solvent-a derivative of castor oil -- that is used to dissolve some insoluble drugs before they can be injected into the blood stream.
The new and improved formulations include pharmaceutically acceptable, water miscible solubilizers other than Cremophor
which are believed to have improved long-term stability and may reduce adverse side-effects relative to existing formulations.
Taxol is a combination of paclitaxel, Cremophor
EL (polyethoxylated castor oil) and ethanol.
This effect was not observed in the presence of the vehicle (1% Cremophor
00 cetearyl alcohol) Cremophor
A 6 (BASF) (Ceteareth-6 (and) stearyl alcohol) 0.
EL in a Krebs-Henseleit solution [(KH) solution: 1 19 mM NaCl, 4.
Animals of the experimental group were administered suspension of the desired test compound orally (made in 3% cremophor
EL and 0.
00 Phase C Cremophor
RH-40 (BASF) (PEG-40 hydrogenatedcastor 0.
Louis, MO, USA) was suspended in 2% Cremophor
EL in saline solution.