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COX-2 inhibitor
(redirected from Coxib)

    Also found in: Encyclopedia, Wikipedia 0.02 sec.
COX-2 inhibitor (kkst)
n.
Any of a class of nonsteroidal anti-inflammatory drugs that cause fewer gastrointestinal side effects by selective inhibition of prostaglandin formation.
COX-2 inhibitor
Cyclooxygenase-2 inhibitor Pain management A class of analgesics with fewer side effects than those of conventional NSAIDs–which inhibit both cyclooxygenases–COX-1 and COX-2; COX-1 protects the gastric mucosa, preventing ulcers, bleeding, and other digestive tract problems. See COX-2, Prostaglandin.


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Though this coxib-specific "prothrombotic mechanism" is still being investigated, the theory goes that by inhibiting the COX-2 enzymes that dilate blood vessels, while allowing the production of the COX-1 enzymes that cause blood platelets to stick, coxibs can create a friendly environment for the formation of dangerous blood clots in some people.
NSAIDs have their limits in treating OA pain by Running & FitNews
In fact, while other agents have been shown to raise blood pressure between 4 and 6% in hypertensives, one coxib in particular appears to raise it by some 25 to 30%.
NSAID use and endurance running: foundations of a patient advisory by Venables, Jeff / AMAA Journal
Also included in other promoted medicines were global sales of Merck's coxib, ARCOXIA, which reached $57 million in the first quarter, compared with $30 million in the first quarter of 2004.
Merck Announces First-Quarter 2005 Earnings Per Share -EPS- of 62 ... by Business Wire
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