Cowden's disease is a hereditary disorder characterized by oropharyngeal fibrosis and multiple hamartomas with potential malignant changes.
Cowden's disease (multiple hamartoma syndrome), first described in 1963 by Lloyd and Dennis, is a rare autosomal-dominant disease.
To our knowledge, there has been no previous report in the literature of Cowden's disease in which the fibrotic lesions affected a vocal fold.
In view of the constellation of clinical features--oropharyngeal fibrosis and papillary lesions on the pharynx, larynx, lips, left vocal fold, and skin-a diagnosis of Cowden's disease was made.
These findings confirmed the diagnosis of Cowden's disease.
In addition to Cowden's disease, the differential diagnosis includes neurofibromatosis, amyloidosis, and multifocal idiopathic fibrosis: