coumarin

coumarin /cou·ma·rin/ (koo´mah-rin)

1. a principle extracted from the tonka bean; it contains a factor, dicumarol, that inhibits hepatic synthesis of vitamin K–dependent coagulation factors, and a number of its derivatives are used as anticoagulants in treating disorders characterized by excessive clotting.

2. any of these derivatives or any synthetic compound with similar activity.

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coumarin

[ko̅o̅′mərin]

a class of orally active anticoagulant agents with warfarin as its prototype.

indications It is prescribed for prophylaxis and treatment of thrombosis and embolism.

contraindications Known hypersensitivity to the drug prohibits its use. It is not prescribed to patients who are at risk for hemorrhage or who are pregnant.

adverse effects The most serious adverse reaction is hemorrhage. Many other drugs interact with this drug to increase or decrease its effect.

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coumarin [koo´mah-rin]

1. a principle extracted from the tonka bean, from which several anticoagulants are derived that inhibit hepatic synthesis of vitamin K–dependent coagulation factors.

2. any of these derivatives.

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coumarin,

n C₉H₆O, derived from a variety of sources, including tonka bean and sweet clover; may also be artificially manufactured.

Coumarin.

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coumarin

1. a principle extracted from the tonka bean, from which several anticoagulants are derived, that inhibits hepatic synthesis of vitamin K-dependent coagulation factors.

2. any of these derivatives.

3. see also dicoumarol.