co-stimulation

(redirected from Costimulation)

co-stimulation

Immunology The delivery of a 2nd signal from an antigen-presenting cell to a T cell, which rescues an activated T cell from anergy, allowing it to produce the lymphokines necessary for production of additional T cells
References in periodicals archive ?
In the first report of the efficacy of this selective T-cell costimulation modulator in patients whose disease duration is 2 years or less and who have an inadequate response to methotrexate but are biologic naive, almost half were in disease remission at year 3, according to Dr.
Larsen points to an emerging class of drugs -- Costimulation blockers -- that target the immune system while sparing other organs and unrelated functions, thus avoiding many of the side effects.
Biologics from other drug classes - the interleukin-6 inhibitor tocilizumab (Roche/Chugai's Actemra/RoActemra), the selective costimulation modulator abatacept (Bristol-Myers Squibb/Ono Pharmaceutical's Orencia), and the B-cell-targeted therapy rituximab (Biogen Idec/Roche/Chugai/Zenyaku Kogyo's Rituxan, Roche's MabThera) - underscore the dominance of the TNF-a inhibitors because these newer agents are reserved for patients who fail to achieve an adequate response to TNF-a inhibitor therapy.
BARCELONA -- The first study to evaluate the response to pneumococcal vaccination in patients with rheumatoid arthritis receiving abatacept found that modulation of T-cell costimulation by this agent did not completely inhibit the humoral response to the vaccine, Dr.
According to the results of two phase III clinical trials to be presented this week at the annual meeting of the American College of Rheumatology (ACR), the investigational biologic abatacept (ab-a-'ta-sept) -- a potential first-in-class T-cell costimulation modulator discovered and developed by Bristol-Myers Squibb Company -- demonstrated significant clinical activity in patients with rheumatoid arthritis.
Although the optimal dosing regimens for administration of both the bone marrow and costimulation blockade have yet to be defined, this strategy warrants prompt evaluation in preclinical primate models.
However, the barriers to entry are high given the number of effective biologic therapies already marketed; these include five tumor necrosis factor-alpha (TNF-a) inhibitors, Bristol-Myers Squibb/Ono Pharmaceutical's selective costimulation modulator Orencia, Roche's MabThera (Roche/Biogen Idec Chugai/Zenyaku Kogyo's B-cell inhibitor Rituxan), and the more recently-launched interleukin-6 (IL-6) inhibitor Actemra/RoActemra from Roche/Chugai.
Impact of T-cell costimulation modulation in patients with undifferentiated inflammatory arthritis or very early rheumatoid arthritis: a clinical and imaging study of abatacept (the ADJUST trial).
The indications and optimal targets for autologous stem cell therapy in SLE, as well as the major indications for biologic therapies like B-cell depletion, inhibition of B-cell differentiation, costimulation blockade, and toleragens.
To investigate the effects of tacrolimus or CsA monotherapy on IL-2 mRNA expression on anti-CD3/antiCD28 mAb costimulation ex vivo, we selected living-donor kidney transplant patients who had received treatment with Prograf (tacrolimus) or CsA before transplantation (Table 1).