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co-stimulation |
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co-stimulation Immunology The delivery of a 2nd signal from an antigen-presenting cell to a T cell, which rescues an activated T cell from anergy, allowing it to produce the lymphokines necessary for production of additional T
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This humoral immune response is augmented by T-helper type II (Th2) lymphocytes, which provide costimulation and induce replication of the B cells. 47,48) Statins bind to an allosteric site within leukocyte function antigen-1 (LFA-1), selectively blocking mediated costimulation of lymphocytes and LFA-1-mediated adhesion, unrelated to their inhibition of HMG-coA reductase. CTLA4-Ig belongs to a new class of therapeutic agents known as costimulation blockers. |
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