Cosmegen


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Cosmegen

 [kos´mĕ-jen]
trademark for a preparation of dactinomycin, an antitumor antibiotic.

Cosmegen

(kŏs′mə-jən)
A trademark for the drug dactinomycin.

Cosmegen

a trademark for an antineoplastic (dactinomycin).

Actinomycin D

A relatively toxic antibiotic produced by Streptomyces spp, which is used as a chemotherapeutic.
Mechanism Inhibits DNA transcription by RNA polymerase.
Indications Rhabdomyosarcoma, Wilms’ tumour, gestational trophoblastic tumour 
Adverse effects Anorexia, nausea, vomiting, myelosuppression with pancytopenia, diarrhoea
References in periodicals archive ?
The only approved drug, Cosmegen (dactinomycin), has been largely replaced by other off-label drugs due to its low efficacy and safety.