Cori cycle


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Co·ri cy·cle

(kō'rē),
the phases in the metabolism of carbohydrate: 1) glycogenolysis in the liver; 2) passage of glucose into the circulation; 3) deposition of glucose in the muscles as glycogen; 4) glycogenolysis during muscular activity and conversion to lactate, which is converted to glycogen in the liver. Also called lactic acid cycle.
Synonym(s): lactic acid cycle
[Carl F. Cori]

Cori cycle

Etymology: Carl F. Cori, American physician, 1896-1984; Gerty T. Cori, American biochemist, 1896-1957; co-Nobel laureates in 1947
a physiological mechanism whereby lactate, produced by glycolysis of glucose in contracting muscle, is converted back to glucose in the liver and returned via the circulation to the muscles.

Co·ri cy·cle

(kō'rē sī'kĕl)
The phases in the metabolism of carbohydrate: 1) glycogenolysis in the liver; 2) passage of glucose into the circulation; 3) deposition of glucose in the muscles as glycogen; and 4) glycogenolysis during muscular activity and conversion to lactate, which is converted to glycogen in the liver.
[Carl F. Cori]

Cori cycle

a biochemical pathway that enables lactic acid produced in the skeletal muscles after exercise to be converted in the liver by GLUCONEOGENESIS to form glucose. The new glucose can either be passed back to muscles via the bloodstream to serve as an energy source, or be stored in the liver as glycogen. The two-way flow of products between muscle and liver was first described by Carl Cori (1896–1984).

Cori,

Carl F., Czech-U.S. biochemist and Nobel laureate, 1896-1984.
Cori cycle - the phases in the metabolism of carbohydrate.
Cori ester - an important intermediate in glycogenesis and glycogenolysis. Synonym(s): D-glucose 1-phosphate

Cori cycle

recycles lactate produced by muscle during anaerobic glycolysis. The lactate is released to the blood, taken up by the liver and converted back to glucose, which is released again to be used by muscle.

Cori cycle

pathway by which muscle lactate contributes to blood glucose. Lactate formed in muscle by glycolysis is transported to the liver and resynthesized to glucose there. Called also lactic acid cycle.
Enlarge picture
Cori cycle. By permission from Kaneko JJ, Harvey JW, Bruss ML, Clinical Biochemistry of Domestic Animals, Academic Press, 1997