cooperativity


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co·op·er·a·tiv·i·ty

(kō-op'er-ă-tiv'i-tē),
A property of certain proteins (often enzymes) in which the binding curves or saturation curves or, in the case of enzymes, a plot of initial rates as a function of initial substrate concentration, are nonhyperbolic; suggests that the binding of a ligand has a different affinity at different ligand concentrations. Both allosterism and hysteresis display cooperativity. Compare: allosterism, hysteresis.

cooperativity

/co·op·er·a·tiv·i·ty/ (ko-op″er-ah-tiv´ĭ-te) the phenomenon of alteration in binding of subsequent ligands upon binding of an initial ligand by an enzyme, receptor, or other molecule with multiple binding sites; the affinity for further binding may be enhanced (positive c.) or decreased (negative c.) .

cooperativity

interaction between some proteins in which the binding of one may increase or decrease binding of the other.
References in periodicals archive ?
In ligand-receptor binding kinetics, for example, the equation is strictly valid only for simultaneous binding of all ligand molecules; for the more likely sequential or independent binding schemes, it applies only for strong positive cooperativity [5,6].
The progressive decrease in Hb-O2 affinity is referred to as cooperativity.
Recently, cognitive narratologists have begun to extend the meaning of the notions "cognition" and mind so as to include aspects of communication and interaction ("affect, cooperativity, exteriority and contextuality" [Palmer 200]).
Taken together, the induction of cutaneous epithelial hyperplasia by E6 and E7 in vivo reflects cooperativity between the two oncoproteins.
Although a large body of work has addressed how to extend the relational data model to incorporate cooperativity, neighbouring information, and/or orderings (2; 3; 10; 11; 13), neither of them have succeeded to fit into the representational and operational uniformity of traditional relational algebra or even to reach a certain degree of generality.
These issues include abortion, euthanasia, genetic engineering, genomics, cooperativity, human evolution, and the sustainability of life on Earth.
Depending on the [alpha] value, the binding of one substrate can favour ([alpha] < 1) or hinder ([alpha] > 1) the binding of the second substrate, leading to a positive or negative effect of allosteric cooperativity.
Palonosetron exhibits allosteric binding and positive cooperativity, unlike granisetron and ondansetron which exhibit simple bimolecular binding and no cooperativity.
Additional features such as sign sensitive delays, cooperativity, and pulse generators were also identified depending on the nature of the interactions in the loop.
Order in a complex system exists as a delicate yet resilient expression of the balance between competition and cooperativity of system elements.
argentatum, negative cooperativity inhibits the chain transfer reaction across a wide range of FPP concentrations, a property possessed in far less degree by H.