antihuman globulin

(redirected from Coombs serum)
Also found in: Encyclopedia.

an·ti·hu·man glob·u·lin

serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against human immunoglobulin, some of which may be used in the direct and indirect Coombs tests.
Synonym(s): Coombs serum

an·ti·hu·man glob·u·lin

(an'tē-hyū'măn glob'yū-lin)
Serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement; used in the direct and indirect Coombs tests.
Synonym(s): Coombs serum.

Coombs,

Robin R.A., English veterinarian and immunologist, 1921–.
Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin
Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test
direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.
Gell and Coombs reaction - see under Gell
indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.