controlled drug substance

(redirected from Controlled drug substances)

controlled drug substance

Any drug or therapeutic agent–commonly understood to include narcotics, with a potential for abuse or addiction, which is held under strict governmental control, as delineated by the Comprehensive Drug Abuse Prevention & Control Act passed in 1970
Controlled drug substances
Schedule I drugs High abuse potential, no accepted medical use in US–Acetorphine, acetyl methadol, allyprodine, α—acetylmethadol, bufotenine, dextromoramide, diethyltryptamine, dimethyltryptamine–DMT, etorphine, heroin, ibogaine, ketobemidone, LSD–N,N-diethyl-D-lysergamide or lysergic acid diethylamide, marijuana, mescaline, PCP–phencyclidine, peyote, phenadoxone, phenampromide, racomoramide, tetrahydrocannibol
Schedule II High abuse potential, potentially leading to severe psychologic or physical dependence; schedule II agents have acceptable medical uses, eg narcotics–alphaprodine, anileridine, cocaine, codeine, diphenoxylate, diprenorphine, etorphine HCl, ethymorphine, hydrocordone, hydromorphone, levorphanol, meperidine, methadone, morphine, oxymorphone, poppy straw concentrates, powdered opium, raw opium, thebaine and non-narcotics–amphetamine, amobarbital, methaqualone, methamphetamine, methaqualone, pentobarbital, percodan, phencyclidine, phenmetrazine, secobarbital
Schedule III High abuse potential, moderate to low physical dependence, and high psychologic dependence potential, with acceptable medical uses, which may be narcotic–eg nalorphine, paregoric, or nonnarcotic–eg aprobarbital, benzphentamine, butabarbital, chlorphentermine, chlortermine, glutethimide, mazindol, methyprylon, phendimetrazine, probarbital, talbutal, thiamylal, thiopental, vinbarbital
Schedule IV Minimal abuse potential, limited physical or psychological dependence potential, nonnarcotic, eg barbital, chloral hydrate, chlordiazepoxide, clonazepam, chlorazepate, dextropropoxyphene, diazepam, diethylpropion, ethchlorvynol, ethinamate, fenfluramine, lorazepam, mebutamate, methobarbital, meprobamate, methohexital, oxazepam, paraldehyde, phenobarbital, phentermine, prazepam
Schedule V Very low abuse/dependence potential–eg brown mixture–opium, some codeine preparations, diphenozylate preparations–Lomotil, ethylmorphine-Cidicol, opium–Donnagel-PG, terpin hydrate, or non-narcotic, eg loperamide
References in periodicals archive ?
We believe Johnson Matthey's expertise and proven track record in the manufacture of controlled drug substances are a natural fit with our unique approach to improving drugs with high abuse potential that is based on creating inherently abuse resistant molecules through chemical modification," commented Travis Mickle, Ph.
With a team of 40 professionals, the pharmaceutical services offered by ProClinical are pre/formulation research & development, analytical services including development, clinical batch manufacturing and packaging, distribution of clinical supplies including Interactive Voice Response System, and complete management of controlled drug substances.

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