GJA1

(redirected from Connexin 43)
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GJA1

A gene on chromosome 6q21-q23.2 that encodes an alpha chain of the gap junction protein family, or connexins.

Molecular pathology
GJA1 mutations are associated with oculodentodigital dysplasia and cardiac malformations.
References in periodicals archive ?
Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia.
5 as well as the gap junction protein connexin 43 suggests uniform cardiomyocyte (CMs) development independent of tissue location.
In ovaries, connexin 43 (Cx43), encoded by Gja1, has been found to be the main connexin expressed in developing follicles forming the gap junctions coupling granulosa cells (20-23).
Suppression of connexin 43 and E-cadherin transcripts in in vitro derived bovine embryos following culture in vitro or in vivo in the homologous bovine oviduct.
16-19) Grueterich et al (14) have studied the modulation of connexin 43 (Cnx43) and keratin 3/12 (K3/K12) expression on the cells cultured over the intact and denuded membrane with and without the presence of 3T3 feeder layer.
Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin 43.
5, Ultraclone, Isle of Wight, UK, dilution 1/3000), rabbit antiserum to the small conductance calcium activated potassium channel SK3, a marker for Kit negative fibroblast-like cells (FLC) (8) (Alomone Labs, Jerusalem, Israel dilution 1/300) and rabbit antiserum to Connexin 43 (Cx43, Chemicon, Temecula, CA, dilution 1/100).
Tests showed that the product boosts keratinocyte differentiation by stimulating the expression of caspase-14 and improves intercellular connections by boosting the expression of connexin 43, a major component of gap junctions involved in cell-to-cell communication.
25-50 [micro]M) for 6 hr produced significant increases in IL-6, IL-1[alpha], heat shock protein 70, and connexin 43 (Cx43).