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an abnormality of electrolyte metabolism produced by excessive secretion of aldosterone, it may be primary or occur secondarily in response to extra-adrenal disease. There may be hypertension, hypokalemia, alkalosis, muscular weakness, polyuria, and polydipsia. Called also hyperaldosteronism.
primary aldosteronism that arising from oversecretion of aldosterone, characterized typically by hypokalemia, alkalosis, muscular weakness, polyuria, polydipsia, hypertension, cardiac irregularity, and tetany. The most common etiologic factors are adrenal adenoma, idiopathic hyperplasia of the adrenal cortex, and occasionally carcinoma of the adrenal gland. Most adenomas affect only one of the two glands and therefore can be removed surgically without depriving the patient of a sufficient supply of adrenal cortical hormones. If removal of both glands is necessary, this creates a serious and potentially fatal insufficiency of the hormones. Called also Conn's syndrome.
pseudoprimary aldosteronism that caused by bilateral adrenal hyperplasia and having the same signs and symptoms as primary aldosteronism.
secondary aldosteronism that due to extra-adrenal stimulation of aldosterone secretion; it is commonly associated with edematous states, as in nephrotic syndrome, hepatic cirrhosis, heart failure, and accelerated hypertension.
Etymology: Jerome W. Conn, American physician, b. 1907; Gk, syn, together, dromos, course
primary aldosteronism, characterized by excessive secretion of aldosterone with symptoms of headache, fatigue, nocturia, and polyuria. The patient may also experience hypertension, hypokalemic alkalosis, potassium depletion, and hypervolemia. It may be caused by adrenal hyperplasia or an aldosterone-secreting adenoma.
Conn's syndromeA rare condition caused by a tumour of the cells in an adrenal gland which secrete the hormone ALDOSTERONE. The result is overproduction of this hormone with salt and water retention and a resulting excess of fluid in the tissues (OEDEMA), and high blood pressure (HYPERTENSION). (Jerome William Conn, American physician, b. 1907).
A disorder caused by excessive aldosterone secretion by a benign tumor of one of the adrenal glands. This results in malfunction of the body's salt and water balance and subsequently causes hypertension. Symptoms include thirst, muscle weakness, and excessive urination.
Mentioned in: Plasma Renin Activity