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conjugated estrogen

   Also found in: Acronyms 0.01 sec.
conjugated estrogen
[kon′jəgā′tid]
a mixture of sodium salts of estrogen sulfates, chiefly those of estrone, equilin, and 17-alpha-dihydroequilin. Conjugated estrogens may be prescribed to relieve postmenopausal vasomotor symptoms, such as hot flashes; to treat atrophic vaginitis, female hypogonadism, or primary ovarian failure; and to provide palliation in advanced prostatic carcinoma and metastatic breast cancer in selected patients. The drug is also used to treat and prevent osteoporosis. Continued use of estrogens can increase the risk of endometrial carcinoma, gallbladder disease, and thromboembolic disorders. Because of the danger of damage to the fetus, all female sex hormones are contraindicated during pregnancy. Among the adverse effects of conjugated estrogens are breakthrough bleeding, breast tenderness, nausea, headache, water retention, and skin eruptions. Current preliminary evidence suggests that there are no cardiovascular benefits to estrogen use during menopause, evidence that led to early discontinuation of the clinical study and changes in the product labeling. Coronary heart disease, the focus of the study, was actually increased in the treatment group, along with breast cancer, stroke, and thromboembolism. Topical agents rather than systemic estrogen should be used for treating vulvar or vaginal atrophy. Nonestrogen agents are recommended for the treatment and prevention of osteoporosis.


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To reiterate, while it is in Life Extension[R]'s economic interest to sell mass-produced estradiol and/or conjugated estrogen tablets, we instead recommend that women in need of estrogen drugs obtain them from compounding pharmacies that provide the more scientifically substantiated estriol.
Although reef-building corals can take up significant amounts of unconjugated estrone from the water, it is not known whether corals or other organisms similarly can take up conjugated estrogens.
studies, however, the Swedish numbers show no clear evidence of increased breast cancer risk among women who use conjugated estrogen - the kind most commonly prescribed in the United States.
 
 
 
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