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conglutinin

   Also found in: Encyclopedia, Wikipedia 0.01 sec.
conglutinin [kәn-gloo´tĭ-nin]
a nonimmunoglobulin bovine serum protein that aggregates immune complexes with conglutinogen activity (inactivated C3b) in the presence of divalent cations. It has been used as an indicator system, replacing complement fixation, in serologic tests, and in the detection of immune complexes. Not to be confused with immunoconglutinin.
immune conglutinin immunoconglutinin.

conglutinin
a serum protein found in Bovidae which can bind to fixed C3b and cause C3b-coated particles to clump.


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The assays that are used routinely in clinical laboratories are based on (a) precipitation of CICs by polyethylene glycol, (b) interaction of CICs with complement (C1q assay), (c) detection of CICs bound to C3 (Raji cell assay, conglutinin assay), and (d) binding of CICs to Fc-recognizing molecules (mRF assay).
 
 
 
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