Congenital Insensitivity to Pain with Anhidrosis

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A neurologic disorder characterised by impaired nociception with intact cognition and sensation including discriminative touch. While these patients may be mildly retarded, there are no detectable physical abnormalities. Children with CIPA often bite their tongues, suffer corneal damage and may be unaware of fractures
Aetiology Some cases are due to excessive endophin production for which naloxone may be effective. In others, one of several loss-of-function mutations have been identified in the voltage-gated sodium channel SCN9A, preventing forward propagation of nociceptive information to the brain. While it is very rare, CIPA is more common in consanguineous populations including one cohort in northern Sweden and another in Ashkenazi Jews

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No references found			congenital dysphagocytosis congenital ectodermal defect congenital epulis congenital erythropoietic porphyria congenital facial diplegia congenital generalized fibromatosis Congenital Giant Nevus congenital glaucoma congenital goiter congenital gout Congenital heart defects congenital heart disease congenital hemolytic anemia congenital hemolytic jaundice congenital hernia congenital herpes congenital hip dislocation Congenital Hip Dysplasia congenital hypernatremia congenital hypertrophy of the retinal pigment epithelium congenital hypogammaglobulinemia congenital hypoplastic anemia congenital hypothyroidism congenital ichthyosiform erythroderma congenital immunity Congenital Insensitivity to Pain with Anhidrosis congenital jaundice congenital laryngeal stridor congenital leukemia congenital leukemoid reaction congenital lobar emphysema congenital lymphedema congenital malformation Congenital Malignancy congenital megacolon congenital myxedema congenital nevus congenital nonspherocytic hemolytic anemia congenital nystagmus congenital oculofacial paralysis congenital pancytopenia congenital paramyotonia congenital platelet function defect congenital polycystic disease congenital pouch colon congenital pulmonary arteriovenous fistula congenital pyloric stenosis congenital reduced phalanges congenital rubella syndrome congenital scleral crescent congenital scoliosis			Congenital Hypodontia of Maxillary Lateral Incisors congenital hypogammaglobulinemia Congenital Hypomyelinating Neuropathy congenital hypopigmentation congenital hypopigmentation Congenital Hypoplastic Anaemia congenital hypoplastic anemia congenital hypoplastic anemia congenital hypoplastic anemia congenital hypothyroid dysmaturity syndrome Congenital hypothyroidism Congenital hypothyroidism Congenital hypothyroidism Congenital hypotonia Congenital hypotonia Congenital hypotonia congenital hypotrichosis congenital hypotrichosis universalis congenital ichthyosiform erythroderma congenital ichthyosiform erythroderma congenital ichthyosiform erythroderma congenital ichthyosiform erythroderma Congenital ichthyosis Congenital ichthyosis Congenital ichthyosis Congenital Idiopathic Hemolytic Anemia congenital immunity congenital immunodeficiency congenital immunodeficiency congenital immunodeficiency Congenital Insensitivity to Pain with Anhidrosis Congenital iodine-deficiency syndrome Congenital iodine-deficiency syndrome Congenital iodine-deficiency syndrome congenital jaundice congenital joint disease congenital joint disease congenital joint disease congenital joint disease congenital joint disease Congenital Joint Laxity and Dwarfism Congenital kyphosis Congenital kyphosis Congenital kyphosis Congenital lacrimal duct obstruction Congenital Lactic Acidosis Congenital laryngeal stridor Congenital laryngeal stridor congenital lateral rotation of the ulnar congenital lateral rotation of the ulnar congenital leukemia congenital leukemoid reaction Congenital Limb Deficiency Congenital Lipoid Adrenal Hyperplasia congenital lobar emphysema congenital lobar emphysema congenital lobar emphysema congenital lobar emphysema congenital loco congenital loco congenital loco

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