Radial scar, complex sclerosing lesion and risk of breast cancer: analysis of 175 cases in Northern Ireland.
This problem is typically encountered in sclerosing papillomas/ complex sclerosing lesions (CSL).
It is strongly associated with various proliferative lesions, including epithelial hyperplasia, intraductal or sclerosing papilloma, complex sclerosing lesion, calcification, and apocrine changes.
Sclerosing adenosis is part of the spectrum of fibrocystic changes in the breast, and it is strongly associated with various proliferative lesions, including epithelial hyperplasia, intraductal papilloma, complex sclerosing lesions, and apocrine changes.
For those lesions that are greater than 1 cm in size or harbor more proliferative change with greater architectural complexity, the term complex sclerosing lesion
Metaplastic carcinomas arising in association with benign sclerosing lesions are rare lesions in which a neoplastic spindle cell proliferation with varying degrees of cytologic atypia can be recognized extending beyond the boundaries of the complex sclerosing lesion or papilloma.
A single pathologist with subspecialty expertise in breast pathology reviewed hematoxylin-eosin-stained slides from these 55 cases to confirm the benignity of the lesion and to characterize lesion type (radial scar, complex sclerosing lesion, or sclerosing papilloma) and growth pattern (infiltrative or circumscribed).
Radial scar and complex sclerosing lesion
are benign lesions characterized by a proliferation of benign glands and tubules within a fibrous/fibroelastotic connective tissue stroma.
Histologic sections from the excision showed apocrine ductal carcinoma in situ (DCIS) arising in a complex sclerosing lesion
characterized by extensive adenosis with apocrine "atypia" and stromal fibrosis (Figure 2, a through d).
9,11) Recently published studies have also reported an increased incidence of metaplastic spindle cell carcinomas, including FLSCC, in association with papillomas, radial scars, complex sclerosing lesions, nipple adenomas, and squamous metaplasia in the breast.
25) These nodules are frequently associated with papillomas and complex sclerosing lesions.
Complex sclerosing lesions
(radial scars) of the breast can be palpable.