complement system

(redirected from Complement proteins)

com·ple·ment sys·tem

a group of more than 20 serum proteins, some of which can be serially activated and participate in a cascade resulting in cell lysis; the complement system also functions in chemotaxis, opsonization, and phagocytosis.
References in periodicals archive ?
The Fc portion of an antibody plays a critical functional role by binding to various cellular receptors as well as complement proteins, and it is responsible for recruiting other immune system cells to attack the tumor cell resulting in destruction of the targeted cell.
Based on findings that humans with OA have an excess of complement proteins in their joint fluid, researchers explored further.
In the body, complement proteins bind to invading pathogens or dying cells, sparking their destruction by immune cells called macrophages.
Surviving in blood serum despite the presence of active complement proteins is well known as a virulence factor among isolates of Escherichia coli and other members of the Enterobacteriaceae.
The new method will acknowledge that proteins with high levels of EAA can complement proteins with lower levels of EAA, thus ensuring that dietary intake of EAA in mixed diets meets the requirements.
Wiirzner R, Orren A, Potter P, et al Functionally active complement proteins C6 and C7 detected in C6- and C7-deficient individuals.
The system is "activated" either by the interaction of complement proteins with antibody-antigen complexes (classical pathway) or by interaction with the unusual carbohydrate found on the surface of pathogenic (non-self) organisms (lectin and alternative pathways).
In addition, there is evidence that CRP is present in atherosclerotic lesions alongside complement proteins, and animal studies suggest that CRP activates the complement system and aggravates myocardial injury after ischemia-reperfusion in several species (4).
The two enzyme complexes Lambris studied, called C3bB and C3bBD, drive a central step in amplifying the response by complement proteins.
Complement proteins mark both bacterial and dying host cells for elimination by the body's cellular cleanup services and have been implicated in at least 30 diseases, including stroke, myocardial infarction, and age-related macular degeneration.
Binding of CD55 to complement proteins accelerates their decay, and thus disrupts the cascade and prevents damage to host cells.

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