complement system

(redirected from Complement factor)

com·ple·ment sys·tem

a group of more than 20 serum proteins, some of which can be serially activated and participate in a cascade resulting in cell lysis; the complement system also functions in chemotaxis, opsonization, and phagocytosis.
References in periodicals archive ?
We identified complement factor H (fH) and fH-related (fHr) genes controlling MD susceptibility.
Genetic data was also used to identify if they carried a known risk factor for AMD, a version of the complement factor H (CFH) gene, which plays a role in inflammation.
5] The bladder tumour antigen (BTA stat) test is a rapid, non-invasive, qualitative urine test that detects bladder tumour associated antigen (human complement factor H related protein) in urine.
Since the 2005 discovery that certain variations in the gene for complement factor H-a component of the immune system-are associated with major risk for AMD, research groups around the world have conducted genome-wide association studies to identify other loci that affect AMD risk.
Reduced haemolytic activity is noted in complement factor deficiencies, but also during infections or immune complex diseases.
Walter Crinnion, pesticides such as DDT have been shown to cause reduced function of polymorphs; reduced number of plasma responder cells; increased degranulation of mast cells; leukopenia; decreased phagocytic ability of cells; changes in the spleen, thymus, and gland cells; and variation in complement factor.
For example, the complement factor H region, called a locus, has been associated with macular degeneration, a progressive eye disease that can result in blindness; and susceptibility to meningococcal infection,
Furthermore, retinoic acid response elements (RARE) are present in the promoter region of the complement factor H gene and retinoic acid increased the H gene mRNA and protein levels in cells [14].
Complement factor C3c as marker for subclinical inflammation was measured at baseline.
POT-4 inhibits complement factor C3 and interrupts the complement activation cascade.
Our purpose was to investigate the relationship between macular pigment optical density (MPOD), C-reactive protein (CRP), serum lutein and zeaxanthin (L&Z) levels, and variants in the complement factor H (CFH) gene, and to conduct a pilot study on the effect of MPOD augmentation on macular function.

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