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comparative genomic hybridization

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.03 sec.
comparative genomic hybridization,
a cytogenetic technique in which reference DNA and the DNA to be studied, as from a tumor or an embryo, are labeled with green- and red-fluorescing fluorochromes, respectively. Genetic abnormalities are detected by changes in the green-to-red ratio.


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Comparative genomic hybridization demonstrated chromosomal alterations in the 11 cell lines derived from these tumors; all 11 showed significant loss of chromosome 9q, and seven showed significant gain of chromosome 4q.
Regarding the story about using comparative genomic hybridization on preimplantation cells ("It's a boy
Nasdaq:AFFX) and Baylor College of Medicine announced today that Baylor has obtained a non-exclusive, worldwide license to a number of Affymetrix patents covering comparative genomic hybridization (CGH) microarray services in Clinical Laboratory Improvement Amendments (CLIA) environments.
 
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