combinatorial chemistry

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combinatorial chemistry

The branch of chemistry in which a few basic molecules are combined in various ways to yield a large number of different products; often undertaken in pharmaceutical research.

combinatorial chemistry

The science of creating chemical diversity, a chemistry-based platform for systematically assembling known chemical entities—molecular building blocks—in as many different combinations as possible, generating millions of new screenable compounds for rapid drug discovery. The strategy is to assemble every possible combination of a given set of chemical building blocks while simulataneously recording which ones have been used and in what order, then assay the resulting molecules at once and refer to the record to determine the identity of any that look promising.

Drugs developed by traditional synthetic chemistry require an average of 12 years to identify, while combinatorial compounds of potential interest may be identified within a month; most compounds thusfar created are peptides and oligonucleotides. In the pharmaceutical industry, combinatorial “libraries” of millions of compounds may be produced by smaller biotechnology companies, which may be purchased in part or their entirety by larger companies seeking leads for newer therapeutic agents.
 
Phases, CC research
Synthesis, distribution, inventorying, screening.

combinatorial chemistry

The manufacturing of molecules having specific sizes, shapes, or functional characteristics using computer-aided algorithms or design rules.
See also: chemistry
References in periodicals archive ?
Additionally, CombiChem has established two 50%-owned joint ventures.
Dispensette Organic Bottletop Dispensers use proven floating piston mechanism, but also employ new materials that offer better long term compatibility with certain organic solvent and concentrated acids, Ideal for HPLC and combichem laboratories, the dispenser is offered in analog and digital models.
She previously served as senior vice president of finance, chief financial officer, and secretary of Diversa Corporation and held senior management positions with CombiChem, Inc.
Electrospray ionization capabilities of instrument are used in identification of new drug candidates, supporting combichem, determining metabolites and breakdown products of pharmaceuticals and assuring product quality.
Throughout his career at Forward, Fleming has served as acting president of Triangle Pharmaceuticals (NASDAQ:VIRS), Actigen (now Corixa (NASDAQ:CRXA)), GenQuest (now Corixa (NASDAQ:CRXA)) and CombiChem (now DuPont Pharmaceuticals (NYSE:DD)).
Ideal for HPLC and Combichem labs, dispenser is offered in analog and digital models.
Keywords in this release: functional genomics, encoded proteins, therapeutic targets, sequence homology, neuropsychiatry, cardiovascular medicine, endocrinology, oncology, combinatorial chemistry, combichem, compound library, new molecular entities, NME, high-throughput screening, HTS, accelerator mass spectrometry, microdosing, animal/ex vivo models, human drug absorption, HDA, Enterion capsule, pharmacokinetic data, PK data, absorption, distribution, metabolism and excretion data, ADME data.
It has quickly become the preferred high-performance choice for customers performing demanding research in drug development, metabonomics, discovery of peptide biomarkers, combichem analysis, etc.
Also featured is diverse selection of microplates for disciplines such as sample preparation, genomics, high throughput screening, CombiChem and solid phase extraction.
He also has been the Chairman of Vitesse Semiconductor (Nasdaq:VTSS), Redback Networks (Nasdaq:RBAK), Plumtree Software (Nasdaq:PLUM), Verisity Design (Nasdaq:VRST), Cypress Semiconductor (NYSE:CY), Microchip Tech (Nasdaq:MCHP), Combichem (acquired by Dupont).
Kassel served as senior director of DuPont Pharmaceuticals Research Labs and Director of analytical chemistry at CombiChem, Inc.
During the past 10 years, Dr Royston has been involved as a founding member of a number of successful companies such as GeneSys Therapeutics, now Cell Genesys; GenQuest, now Corixa; CombiChem, now part of Bristol Myers Squibb; Sequana Therapeutics, now part of Celera Genomics; Corixa; and GenStar Therapeutics.