pyrantel pamoate (redirected from Combantrin)

pyrantel pamoate

[pīran′təl]

an anthelmintic.

indications It is prescribed in the treatment of infestation by roundworms or pinworms.

contraindications Known hypersensitivity to this drug prohibits its use. Caution should be used in anemia or severe malnutrition.

adverse effects Among the more serious adverse effects are nausea, abdominal cramps, diarrhea, dizziness, and skin rash.

---

pyrantel pamoate

Combantrin (CA), Pin-X, Reese's Pinworm

Pharmacologic class: Pyrimidine derivative

Therapeutic class: Anthelmintic

Pregnancy risk category C

Action

Stimulates ganglionic receptors in worm, paralyzing it; worm is then expelled through normal peristalsis.

Availability

Capsules: 180 mg

Liquid: 50 mg/ml

Oral suspension: 50 mg/ml, 144 mg/ml

⊘Indications and dosages

➣ Pinworm (enterobiasis); roundworm (ascariasis)

Adults and children older than age 2: 11 mg/kg P.O. as a single dose (maximum of 1 g/day), repeated in 2 weeks

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• malnutrition, dehydration, hepatic disease, seizure disorder
• Trichostrongylus infection
• pregnant or breastfeeding patients
• children younger than age 2.

Administration

• Shake suspension well.
• Give all forms without regard to food, milk, or juice intake.

Route	Onset	Peak	Duration
P.O.	Slow	1-3 hr	Unknown

Adverse reactions

CNS: dizziness, headache, drowsiness, insomnia, asthenia

GI: nausea, vomiting, diarrhea, abdominal cramps, gastralgia, anorexia

Skin: rash

Other: fever

Interactions

Drug-drug. Piperazine: antagonism of both drugs' effects

Drug-diagnostic tests. Aspartate aminotransferase: transient increase

Patient monitoring

• Monitor for rash and fever.

Patient teaching

• Tell patient to shake suspension well. Inform him that he may take it with or without food, juice, or milk.
• Instruct patient to report rash or fever.
• If pinworm is suspected, tell patient that everyone in household should be treated.
• Advise patient to practice strict hygiene to prevent reinfection.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and tests mentioned above.